| Algorithm proposal based on the C. Diff Quik Chek Complete ICT device for detecting Clostridium difficile infection. | |
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MedLine Citation:
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PMID: 22341752 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To assess a new immunochromatography (ICT) test that detects glutamate dehydrogenase (GDH) antigen and Clostridium difficile toxin A/B simultaneously, and to propose an algorithm for the diagnosis of C. difficile infection (CDI) based on this test. METHODS: We analysed 970 stool samples. Discrepant results between GDH and toxin A/B were resolved using toxigenic culture as the reference. RESULTS: This test enabled us to obtain a conclusive result in <30min in 93.8% of the samples. Among the discrepant results (GDH (+)/Toxin A/B (-)), 41.7% (25/60) were found to be toxigenic C. difficile by toxigenic culture. CONCLUSION: This test has a high sensitivity and specificity for the diagnosis of CDI. |
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Authors:
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M A Angeles Orellana-Miguel; Adela Alcolea-Medina; Laura Barrado-Blanco; Joaquín Rodriguez-Otero; Fernando Chaves-Sánchez |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-15 |
Journal Detail:
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Title: Enfermedades infecciosas y microbiologia clinica Volume: - ISSN: 1578-1852 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104081 Medline TA: Enferm Infecc Microbiol Clin Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier España, S.L. All rights reserved. |
Affiliation:
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Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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