Document Detail


Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit.
MedLine Citation:
PMID:  11858616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of alginic acid addition to 1% or 2% carteolol solutions on the ocular penetration of the drug has been evaluated in the pigmented rabbit. During single dose studies, an increase in bioavailability ranging from 40% to 60% was observed in the aqueous humor and in the iris-ciliary body. During repeated dose studies, this increased ocular bioavailability of carteolol in the presence of alginic acid led to an equivalent concentration in the target tissue, although the dosage was only once a day compared with twice a day for the usual carteolol eyedrops. 14C-carteolol distribution studies demonstrated the binding of carteolol in pigmented ocular tissues. Thus, the presence of alginic acid as a new excipient supports a possible decrease in dosage regimen, while retaining sufficient ocular bioavailability to lower intraocular pressure.
Authors:
G Tissié; C Sébastian; P P Elena; J Y Driot; C Trinquand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics     Volume:  18     ISSN:  1080-7683     ISO Abbreviation:  J Ocul Pharmacol Ther     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-22     Completed Date:  2002-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9511091     Medline TA:  J Ocul Pharmacol Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  65-73     Citation Subset:  IM    
Affiliation:
Centre de Recherche, Laboratoire Bausch & Lomb/Chauvin, Montpellier, France. gtissie@chauvingroup.com
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacokinetics*
Alginates / pharmacology*
Animals
Carteolol / administration & dosage,  pharmacokinetics*
Eye / metabolism*
Glucuronic Acid
Hexuronic Acids
Pigmentation / physiology*
Rabbits
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Alginates; 0/Hexuronic Acids; 51781-06-7/Carteolol; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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