| Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit. | |
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MedLine Citation:
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PMID: 11858616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of alginic acid addition to 1% or 2% carteolol solutions on the ocular penetration of the drug has been evaluated in the pigmented rabbit. During single dose studies, an increase in bioavailability ranging from 40% to 60% was observed in the aqueous humor and in the iris-ciliary body. During repeated dose studies, this increased ocular bioavailability of carteolol in the presence of alginic acid led to an equivalent concentration in the target tissue, although the dosage was only once a day compared with twice a day for the usual carteolol eyedrops. 14C-carteolol distribution studies demonstrated the binding of carteolol in pigmented ocular tissues. Thus, the presence of alginic acid as a new excipient supports a possible decrease in dosage regimen, while retaining sufficient ocular bioavailability to lower intraocular pressure. |
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Authors:
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G Tissié; C Sébastian; P P Elena; J Y Driot; C Trinquand |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics Volume: 18 ISSN: 1080-7683 ISO Abbreviation: J Ocul Pharmacol Ther Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-22 Completed Date: 2002-11-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9511091 Medline TA: J Ocul Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 65-73 Citation Subset: IM |
Affiliation:
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Centre de Recherche, Laboratoire Bausch & Lomb/Chauvin, Montpellier, France. gtissie@chauvingroup.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacokinetics* Alginates / pharmacology* Animals Carteolol / administration & dosage, pharmacokinetics* Eye / metabolism* Glucuronic Acid Hexuronic Acids Pigmentation / physiology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Alginates; 0/Hexuronic Acids; 51781-06-7/Carteolol; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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