Document Detail

Alginic Acid Nanoparticles Prepared through Counter-Ion Complexation Method as a Drug Delivery System.
MedLine Citation:
PMID:  23020277     Owner:  NLM     Status:  Publisher    
In this paper, a kind of novel alginic acid nanoparticles was successfully prepared by a nonsolvent-aided counterion complexation between anionic alginic acid and cationic 2,2'-(ethylenedioxy)diethylamine in aqueous solution followed by cross-linking alginic acid moiety using Ca2+. It was found that these alginic acid nanoparticles have a spherical morphology with the diameter of about 100 nm, and negatively charged surface with the zeta potential of about -30 mV. Compared to the desintegrity of uncrosslinked nanoparticles, the Ca2+-crosslinked nanoparticles maintained their integrity in the aqueous medium with the physiological pH value. Doxorubucin, a model antitumor drug, was successfully loaded into the alginic acid nanoparticles, and their in vitro and in vivo antitumor activities were evaluated. It was found that these negatively charged nanoparticles could be taken up by the cancer cells through an endocytosis mechanism. In vivo near-infrared (NIR) fluorescence imaging and biodistribution examinations showed that the alginic acid nanoparticles could be well accumulated in the tumor site by the enhanced permeability and retention effect. In vivo antitumor examination showed that the drug-loaded nanoparticles have superior efficacy in impeding tumor growth and prolonging the lifetime of H22 tumor-bearing mice than free drug.
Yuan Cheng; Shuling Yu; Xu Zhen; Xin Wang; Wei Wu; Xiqun Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  ACS applied materials & interfaces     Volume:  -     ISSN:  1944-8252     ISO Abbreviation:  ACS Appl Mater Interfaces     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504991     Medline TA:  ACS Appl Mater Interfaces     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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