Document Detail

Alfred Blalock and thymectomy for myasthenia gravis.
MedLine Citation:
PMID:  3548618     Owner:  NLM     Status:  MEDLINE    
In 1936, Alfred Blalock performed the successful removal of a thymic tumor in a patient with myasthenia gravis. The patient experienced marked and sustained improvement for several years. Blalock prophesized then that exploration of the thymic region would be indicated in all patients with severe myasthenia gravis. A few years later, in 1941, he applied this theory by introducing thymectomy for nonthymomatous myasthenia and achieved similar improvement. Despite modern sophisticated knowledge about the disease and advances in thoracic surgical techniques, Blalock's original observations remain valid, and thymectomy has become a standard treatment for myasthenia gravis the world over.
P A Kirschner
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Publication Detail:
Type:  Biography; Historical Article; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  43     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-04-08     Completed Date:  1987-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  348-9     Citation Subset:  AIM; IM; Q    
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MeSH Terms
History, 20th Century
Myasthenia Gravis / history*,  surgery
Thymectomy / history*,  methods
United States
Personal Name Subject
Personal Name Subject:
A Blalock

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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