Document Detail

Alexithymia in Noonan syndrome.
MedLine Citation:
PMID:  15083699     Owner:  NLM     Status:  MEDLINE    
Although Noonan syndrome is quite prevalent, there is a general paucity in the description of psychological and psychiatric aspects. In the present paper a 19-year-old female patient with Noonan syndrome is described who presented with anxiety symptoms. Mutation analysis in PTPN11, the NS1 gene on chromosome 12q24, showed no abnormalities. A diagnosis of panic disorder without agoraphobia was established. Treatment with citalopram resulted in a gradual decline of anxiety symptoms. The psychological profile was characterized by a prominent alexithymia. The main conclusion is that patients with Noonan syndrome might have deficits in emotional adaptative functions. It is hypothesized that alexithymia is a key feature of the behavioural phenotype.
W M Verhoeven; J L Hendrikx; M C MDoorakkers; J I Egger; I Van der Burgt; S Tuinier
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Genetic counseling (Geneva, Switzerland)     Volume:  15     ISSN:  1015-8146     ISO Abbreviation:  Genet. Couns.     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-07-20     Revised Date:  2006-07-06    
Medline Journal Info:
Nlm Unique ID:  9015261     Medline TA:  Genet Couns     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.
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MeSH Terms
Abnormalities, Multiple
Affective Symptoms / diagnosis,  drug therapy,  etiology*
Agoraphobia / complications,  diagnosis,  drug therapy
Chromosomes, Human, Pair 12 / genetics
Citalopram / therapeutic use
Noonan Syndrome / genetics*,  psychology*
Panic Disorder / complications,  diagnosis,  drug therapy
Serotonin Uptake Inhibitors / therapeutic use
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 59729-33-8/Citalopram

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