| Alexia and agraphia with lesions of the angular and supramarginal gyri: evidence for the disruption of sequential processing. | |
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MedLine Citation:
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PMID: 19896678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the features of alexia or agraphia with a left angular or supramarginal gyrus lesion. METHODS: We assessed the reading and writing abilities of three patients using kanji (Japanese morphograms) and kana (Japanese syllabograms). RESULTS: Patient 1 showed kana alexia and kanji agraphia following a hemorrhage in the left angular gyrus and the adjacent lateral occipital gyri. Patient 2 presented with minimal pure agraphia for both kanji and kana after an infarction in the left angular gyrus involving part of the supramarginal gyrus. Patient 3 also showed moderate pure agraphia for both kanji and kana after an infarction in the left supramarginal and postcentral gyri. All three patients made transposition errors (changing of sequential order of kana characters) in reading. Patient 1 showed letter-by-letter reading and a word-length effect and made substitution errors (changing hiragana [one form of kana] characters in a word to katakana [another form of kana] characters and vice versa) in writing. CONCLUSION: Alexia occurs as "angular" alexia only when the lesion involves the adjacent lateral occipital gyri. Transposition errors suggest disrupted sequential phonological processing from the angular and lateral occipital gyri to the supramarginal gyrus. Substitution errors suggest impaired allographic conversion between hiragana and katakana attributable to a dysfunction in the angular/lateral occipital gyri. |
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Authors:
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Yasuhisa Sakurai; Masahiko Asami; Toru Mannen |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-11-06 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 288 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 25-33 Citation Subset: IM |
Affiliation:
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Department of Neurology, Mitsui Memorial Hospital, Tokyo, Japan. ysakurai-tky@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Agraphia / pathology*, physiopathology Dyslexia / pathology*, physiopathology Female Handwriting Humans Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Parietal Lobe / pathology*, physiopathology Psychomotor Performance / physiology Reading |
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