Document Detail

"Aleukemic" granulomatous leukemia cutis.
MedLine Citation:
PMID:  9700385     Owner:  NLM     Status:  MEDLINE    
Aleukemic leukemia cutis is a rare condition characterized by the infiltration of the skin by leukemic cells before their appearance in the peripheral blood. The authors report a case of aleukemic leukemia cutis in a 30-year-old seemingly healthy man who presented with multiple skin papulonodular lesions and lack of peripheral blood involvement. Histopathologically, the skin infiltrates showed prominent granulomatous features that masked the underlying malignant process. Immunophenotypic studies of skin and bone marrow infiltrates revealed the myelomonocytic lineage of the atypical cells, consistent with M4 acute myelomonocytic leukemia. The authors emphasize the value of immunohistochemical studies in diagnosing a cutaneous atypical infiltrate and discuss problems of histopathologic differential diagnosis.
C Tomasini; P Quaglino; M Novelli; M T Fierro
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  20     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-14     Completed Date:  1998-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  417-21     Citation Subset:  IM    
Department of Medical and Surgical Specialities, University of Turin, Italy.
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MeSH Terms
Granuloma / pathology*
Leukemia, Myelomonocytic, Acute / pathology*
Leukemic Infiltration*
Skin Diseases, Papulosquamous / pathology*

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