Document Detail


Alert response to motion onset in the retina.
MedLine Citation:
PMID:  23283327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown that motion onset is very effective at capturing attention and is more salient than smooth motion. Here, we find that this salience ranking is present already in the firing rate of retinal ganglion cells. By stimulating the retina with a bar that appears, stays still, and then starts moving, we demonstrate that a subset of salamander retinal ganglion cells, fast OFF cells, responds significantly more strongly to motion onset than to smooth motion. We refer to this phenomenon as an alert response to motion onset. We develop a computational model that predicts the time-varying firing rate of ganglion cells responding to the appearance, onset, and smooth motion of a bar. This model, termed the adaptive cascade model, consists of a ganglion cell that receives input from a layer of bipolar cells, represented by individual rectified subunits. Additionally, both the bipolar and ganglion cells have separate contrast gain control mechanisms. This model captured the responses to our different motion stimuli over a wide range of contrasts, speeds, and locations. The alert response to motion onset, together with its computational model, introduces a new mechanism of sophisticated motion processing that occurs early in the visual system.
Authors:
Eric Y Chen; Olivier Marre; Clark Fisher; Greg Schwartz; Joshua Levy; Rava Azeredo da Silveira; Rava Azeredo da Silviera; Michael J Berry
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-03-12     Revised Date:  2013-08-29    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-32     Citation Subset:  IM    
Affiliation:
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology*
Ambystoma
Animals
Attention / physiology
Motion
Motion Perception / physiology*
Retina / physiology*
Retinal Ganglion Cells / physiology*
Grant Support
ID/Acronym/Agency:
EY017934/EY/NEI NIH HHS; R01 EY017934/EY/NEI NIH HHS
Comments/Corrections
Erratum In:
J Neurosci. 2013 Feb 6;33(6):2728
Note: da Silviera, Rava Azeredo [corrected to da Silveira, Rava Azeredo]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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