Document Detail

Aldrin epoxidation and dihydroisodrin hydroxylation as probes of in vivo and in vitro oxidative metabolic capability of some caterpillars.
MedLine Citation:
PMID:  18432628     Owner:  NLM     Status:  MEDLINE    
Comparative biochemical studies are productive means to study factors that limit both beneficial and harmful effects of chemicals. Reactions such as aldrin epoxidation and dihydroisodrin hydroxylation are valuable assays of oxidative metabolism in scientific studies of chemical biology in insects, subhuman primates and other living things. The tissue distribution of activity in caterpillars may have functional significance. Localization of relatively high concentrations of these cytochrome P450 monooxygenases in gut tissue of lepidoptera may represent an important means to minimize absorption of lipophilic foreign chemicals in food. Some polychlorocycloalkanes permit in vivo and in vitro studies owing to their stability, acceptable toxicity and relatively simple pattern of metabolism. In vivo studies to assess the significance of in vitro findings are feasible with substrates such as aldrin, dihydroisodrin (DHI) and oxidative methylenedioxyphenyl inhibitors such as piperonyl butoxide (PBO) or carbon monoxide. Biphasic dose-dependent decreased and increased DHI-OH formation resulted from PBO pretreatment by gut, fat body, head and Malpighian tubule homogenates of cutworms and gut and fat body (the only tissues tested) of cabbage looper Trichplusia ni (Hübner) and black cutworm Agrotis ipsilon (Hüfnagel). The biphasic in vivo responses of caterpillars to PBO are a reminder of the complexity of biochemical and physiological responses of organisms coexposed to chemicals that are classified, often glibly, as toxic substances and metabolic inhibitors and inducers. Knowledge of dose and time relationships demands very careful evaluation in living things in the environment.
Robert I Krieger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pest management science     Volume:  64     ISSN:  1526-498X     ISO Abbreviation:  Pest Manag. Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898744     Medline TA:  Pest Manag Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  622-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Society of Chemical Industry.
Personal Chemical Exposure Program, 10 Chapman Hall, Department of Entomology, Environmental Toxicology Graduate Program, University of California, Riverside, CA 9252, USA.
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MeSH Terms
Aldrin / chemistry,  metabolism*
Cytochrome P-450 Enzyme System / metabolism
Hydrocarbons, Chlorinated / chemistry,  metabolism*
Larva / drug effects
Molecular Structure
Pesticide Synergists / pharmacology
Piperonyl Butoxide / pharmacology
Spodoptera / metabolism*
Reg. No./Substance:
0/Hydrocarbons, Chlorinated; 0/Pesticide Synergists; 2387-13-5/dihydroisodrin; 309-00-2/Aldrin; 51-03-6/Piperonyl Butoxide; 9035-51-2/Cytochrome P-450 Enzyme System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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