Document Detail

Aldosteronism revisited: perspectives on less well-recognized actions of aldosterone.
MedLine Citation:
PMID:  12960953     Owner:  NLM     Status:  MEDLINE    
Aldosterone is a mineralocorticoid with protean actions in both epithelial and nonepithelial cells. These include endocrine properties of circulating aldosterone that promote Na(+) resorption at the expense of well-recognized K(+) excretion and less well-recognized Mg(2+) excretion in classic target tissues: kidneys, colon, and sweat and salivary glands. The regulation of adrenal aldosterone secretion by [Mg(2+)](o) is also less well appreciated. More recently recognized endocrine actions of aldosterone include induction of Mg(2+) efflux in exchange for Na(+) in such nonepithelial cells as peripheral-blood mononuclear cells and influence on epithelial cells of the choroid plexus, where aldosterone alters the composition of cerebrospinal fluid that contributes to blood-pressure regulation. An association between primary aldosteronism and idiopathic intracranial hypertension has recently been reported. Extraadrenal steroidogenesis with de novo aldosterone production by the cardiovasculature, where its auto-/paracrine properties may contribute to tissue repair at sites of injury, has been observed. These less well-recognized actions of aldosterone have led to a revival of interest in how this steroid molecule contributes to the pathophysiology of various clinical disorders.
Karl T Weber
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  142     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-08     Completed Date:  2003-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-82     Citation Subset:  AIM; IM    
Division of Cardiovascular Diseases, University of Tenesse Health Science Center, TN 38163, USA.
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MeSH Terms
Aldosterone / physiology*
Hyperaldosteronism / metabolism*,  physiopathology*
Reg. No./Substance:

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