| Aldosterone studies in obese patients with hypertension. | |
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MedLine Citation:
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PMID: 3890539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten patients with hypertension and obesity were studied during a program of weight loss on an unrestricted sodium diet. The study showed that weight loss during the ten month period was accompanied by a significant decrease in urinary aldosterone, tetrahydroaldosterone -3-glucuronide and plasma renin activity values. It was also demonstrated that successful reduction in body weight was associated with a reduction in blood pressure. It is postulated that blood pressure reduction in obese patients during weight reduction may depend on decreases in aldosterone and plasma renin activity. The reduction in levels of tetrahydroaldosterone-3-glucuronide is due to an energy related depression of the glucuronidation process caused by carbohydrate deficiency. It is postulated that the lowered rate of metabolism of aldosterone as measured by the diminished formation of the metabolite tetrahydroaldosterone-3-glucuronide is an important determinant of blood pressure status during weight reduction. |
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Authors:
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P Marks; B Wilson; A Delassalle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 289 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 1985 Jun |
Date Detail:
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Created Date: 1985-07-15 Completed Date: 1985-07-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 224-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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analogs & derivatives,
metabolism*,
urine Blood Pressure Body Weight Diet, Reducing Humans Hypertension / complications, metabolism*, physiopathology, therapy Natriuresis Obesity / complications, metabolism*, physiopathology, therapy Potassium / blood Renin / blood |
| Chemical | |
Reg. No./Substance:
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20605-81-6/tetrahydroaldosterone 3 beta-glucosiduronic acid; 52-39-1/Aldosterone; 7440-09-7/Potassium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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