| Aldosterone and specific aldosterone receptor antagonists in hypertension and cardiovascular disease. | |
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MedLine Citation:
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PMID: 12642011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent preclinical and clinical studies indicate that aldosterone, independent of angiotensin II and elevated blood pressure, may play a role in health and disease. In addition to its role in fluid and electrolyte balance and circulatory homeostasis, more recent studies have identified aldosterone as a critical mediator of vascular damage. In animal studies, aldosterone is implicated in cardiac and vascular fibrosis, renal disease, and cerebrovascular damage. These lesions are prevented by specific aldosterone receptor blockade. In clinical studies, aldosterone receptor antagonism is associated with decreased hospitalization, symptomatology, and mortality, and improvement of endothelial dysfunction in patients with chronic heart failure. A better understanding of aldosterone's actions in nonepithelial tissues should pave the way to better protection of organs at risk such as the kidneys, heart, and brain. |
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Authors:
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Emmanuel L Bravo |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current hypertension reports Volume: 5 ISSN: 1522-6417 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-18 Completed Date: 2003-05-08 Revised Date: 2006-07-12 |
Medline Journal Info:
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Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
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Languages: eng Pagination: 122-5 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Hypertension, Cleveland Clinic Foundation, 9500 Euclid Avenue - Desk A51, OH 44195, USA. bronofs@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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physiology* Aldosterone Antagonists / therapeutic use* Angiotensin-Converting Enzyme Inhibitors / therapeutic use Animals Cardiovascular Diseases / drug therapy, physiopathology* Endothelium, Vascular / physiopathology Humans Hypertension / drug therapy, physiopathology* Receptors, Aldosterone / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Aldosterone; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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