Document Detail

Aldosterone responses to angiotensin II in anorexia nervosa.
MedLine Citation:
PMID:  1471538     Owner:  NLM     Status:  MEDLINE    
Patients with anorexia nervosa (AN) tend to have renin-angiotensin-aldosterone (RAA) abnormalities caused by abnormal behaviors such as strict dieting, fasting, vigorous exercise, self-induced vomiting and abuse of laxatives and/or diuretics. Adrenal responsiveness to angiotensin II (A II) was studied in 13 AN patients before and after therapy and in 6 normal sex- and age-matched controls: adrenal responses to postural change (1 h of walking following 1 h in a supine position) and to exogenous A II injection (A II: 10 ng/kg/min intravenous infusion for 30 min). The 24-h urine sodium concentration was significantly lower in AN patients before therapy than after therapy. Plasma aldosterone secretory response to A II was significantly higher in AN patients before therapy in both postural change and exogenous A II injection tests compared with after therapy response and that of controls. On the other hand, there was no significant difference in adrenal response to postural change or to exogenous A II between AN patients after therapy and controls. In conclusion, increased A II sensitivity caused by chronic sodium deficiency in AN patients normalized over time as the patients recovered.
O Mizuno; H Tamai; M Fujita; N Kobayashi; G Komaki; S Matsubayashi; T Nakagawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  86     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-27     Completed Date:  1993-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  450-4     Citation Subset:  IM    
Department of Psychosomatic Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Aldosterone / blood*
Angiotensin II / diagnostic use*
Anorexia Nervosa / diagnosis,  physiopathology*,  psychology
Body Weight / physiology
Cognitive Therapy
Electrolytes / blood
Exercise Test
Renin-Angiotensin System / physiology
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Electrolytes; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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