| Aldosterone and refractory hypertension. | |
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MedLine Citation:
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PMID: 17940442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Evidence from clinical trials suggests that refractory hypertension is increasingly common. The underlying mechanisms are largely unknown but recent data have implicated increased aldosterone activity as an important mediator of resistance to routinely used antihypertensive agents. RECENT FINDINGS: Epidemiological studies have suggested a significant rise in the prevalence of primary aldosteronism among patients with hypertension. This reflects the increasing use of an aldosterone-to-renin ratio as a screening tool. Recent reports have demonstrated that relative aldosterone excess is common in individuals with refractory hypertension, and that the use of aldosterone antagonists leads to better blood pressure control in such patients. SUMMARY: These data highlight the potential role of aldosterone in the pathogenesis of hypertension. The syndrome of primary aldosteronism, however, encompasses a wide spectrum of disorders that will require better definition. Similarly, although aldosterone blockade is apparently beneficial in individuals with refractory hypertension, this evidence is not currently based on robust randomized, double-blind trial. |
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Authors:
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Moffat J Nyirenda; Paul L Padfield |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in endocrinology, diabetes, and obesity Volume: 14 ISSN: 1752-2978 ISO Abbreviation: - Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-10-17 Completed Date: 2008-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101308636 Medline TA: Curr Opin Endocrinol Diabetes Obes Country: England |
Other Details:
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Languages: eng Pagination: 213-8 Citation Subset: IM |
Affiliation:
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Endocrinology Unit, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism* Aldosterone Antagonists / therapeutic use Antihypertensive Agents / therapeutic use* Blood Pressure / drug effects Drug Resistance Humans Hyperaldosteronism / complications, epidemiology Hypertension / complications, drug therapy*, etiology, physiopathology* Incidence |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Antihypertensive Agents; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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