| Aldosterone-receptor antagonism in hypertension. | |
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MedLine Citation:
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PMID: 19516169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the renin-angiotensin-aldosterone system (RAAS) in hypertension has since long been recognized and aldosterone has been acknowledged as one of the key hormones in the pathophysiology, not only in primary aldosteronism but also in essential hypertension and drug-resistant hypertension. Aldosterone-receptor antagonists (ARAs) are increasingly used in patients with resistant hypertension, often with impressive results. However, definitive evidence for the benefit of ARAs in these patients from randomized, controlled trials is lacking. This review gives an overview of the current data on this topic. Future studies should focus on the identification of factors that are able to predict the response to treatment, as to select patients who will benefit most from treatment with ARAs. On the basis of the current knowledge, we recommend prescription of ARAs to patients with primary aldosteronism, resistant hypertension and patients with hypertension and hypokalemia. |
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Authors:
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Pieter M Jansen; A H Jan Danser; Ben P Imholz; Anton H van den Meiracker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 27 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-06-11 Completed Date: 2009-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 680-91 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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etiology Aldosterone / physiology Angiotensin-Converting Enzyme Inhibitors / therapeutic use Animals Arrhythmias, Cardiac / etiology Drug Therapy, Combination Electrocardiography Fibrosis Glomerular Filtration Rate Humans Hypertension / drug therapy*, etiology Hypertrophy, Left Ventricular / drug therapy Myocardium / pathology Receptors, Aldosterone / antagonists & inhibitors* Spironolactone / adverse effects, analogs & derivatives, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Receptors, Aldosterone; 0/eplerenone; 52-01-7/Spironolactone; 52-39-1/Aldosterone |
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