| Aldosterone-producing adenoma without hypertension: a report of two cases. | |
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MedLine Citation:
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PMID: 10474126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normotensive primary hyperaldosteronism is exceedingly rare. We report two new cases of this syndrome in two middle-aged women, one of Asian origin. The presenting signs were tetany in one case and an adrenal mass in the other. Neither patient had hypertension, despite repeated measurements with a manual armlet. A typical biological profile of primary hyperaldosteronism was demonstrated in both patients, including hypokalemia with inappropriate kaliuresis, elevated resting plasma aldosterone, and undetectable plasma renin activity. The circadian rhythm of blood pressure was studied by ambulatory monitoring pre- and post-operatively. It confirmed the lack of hypertension, but the circadian rhythm of blood pressure was lost before surgery in one patient. Surgical removal of the histologically typical aldosterone-producing adenomas normalized the kalemia. The main finding in these two patients was spontaneously low blood pressure in the post-operative period. This suggests that excess aldosterone induced relative hypertension in these patients whose blood pressure was spontaneously very low. Genetic screening for dexamethasone-sensitive hyperaldosteronism was negative in both patients. |
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Authors:
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M C Vantyghem; N Ronci; F Provost; A Ghulam; J Lefebvre; X Jeunemaitre; A Tabarin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 141 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-11-12 Completed Date: 1999-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 279-85 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, CHRU, 59037 Lille Cedex, France. avantyghem@infonie.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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secretion*,
surgery Adrenal Gland Neoplasms / physiopathology*, surgery Adult Aldosterone / blood, secretion*, urine Atrial Natriuretic Factor / blood Blood Pressure Monitoring, Ambulatory Blotting, Southern Chromatography, High Pressure Liquid Dexamethasone / pharmacology Female Gas Chromatography-Mass Spectrometry Humans Hyperaldosteronism / genetics, physiopathology*, surgery Hypertension / complications*, physiopathology Potassium / blood, urine Radioimmunoassay Renin / blood Tetany Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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50-02-2/Dexamethasone; 52-39-1/Aldosterone; 7440-09-7/Potassium; 85637-73-6/Atrial Natriuretic Factor; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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