Document Detail

Aldosterone-producing-adenoma (A-P-A): effect of pregnancy.
MedLine Citation:
PMID:  6754149     Owner:  NLM     Status:  MEDLINE    
Serial measurements of plasma renin activity, plasma progesterone and urinary aldosterone were made before, during and after pregnancy in a patient from whom an A-P-A was later removed with cure of hypertension and hypokalemia. Despite 16-fold increases in urinary aldosterone during pregnancy, plasma renin activity levels became unsuppressed, and hypertension and hypokalemia were reversed. Increases in plasma progesterone or other steroids, competitively inhibiting the effects of aldosterone on its receptor, may explain remission of A-P-A and reversal of renin suppression during pregnancy. In a second patient, the features of primary aldosteronism appeared immediately after a pregnancy, and removal of an A-P-A cured hypertension and hypokalemia. A-P-A is more common in females and may appear following pregnancy. Urinary aldosterone was 6-fold higher after pregnancy than before. Thus, sex steroids may not only protect from hyperaldosteronism but may also stimulate growth of A-P-A's.
R D Gordon; T J Tunny
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  4     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1685-93     Citation Subset:  IM    
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MeSH Terms
Adenoma / blood,  complications,  secretion*
Adrenal Gland Neoplasms / blood,  complications,  secretion*
Aldosterone / secretion*,  urine
Pregnancy Complications, Neoplastic / blood*
Progesterone / blood
Renin / blood
Reg. No./Substance:
52-39-1/Aldosterone; 57-83-0/Progesterone; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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