| Aldosterone paradox: differential regulation of ion transport in distal nephron. | |
| | |
MedLine Citation:
|
PMID: 21487030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance. |
| | |
Authors:
|
Juan Pablo Arroyo; Caroline Ronzaud; Dagmara Lagnaz; Olivier Staub; Gerardo Gamba |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Physiology (Bethesda, Md.) Volume: 26 ISSN: 1548-9221 ISO Abbreviation: Physiology (Bethesda) Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-13 Completed Date: 2011-08-10 Revised Date: 2011-11-28 |
Medline Journal Info:
|
Nlm Unique ID: 101208185 Medline TA: Physiology (Bethesda) Country: United States |
Other Details:
|
Languages: eng Pagination: 115-23 Citation Subset: IM |
Affiliation:
|
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
physiology* Animals Humans Ion Transport / physiology Kidney Tubules, Distal / physiology* Potassium / metabolism Sodium Chloride / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
DK-64635/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
52-39-1/Aldosterone; 7440-09-7/Potassium; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
|
Physiology (Bethesda). 2011 Oct;26(5):307; author reply 308
[PMID:
22013188
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterogeneous cardiac proteasomes: mandated by diverse substrates?
Next Document: Remodeling the cardiac transcriptional landscape with diet.