Document Detail

Aldosterone paradox: differential regulation of ion transport in distal nephron.
MedLine Citation:
PMID:  21487030     Owner:  NLM     Status:  MEDLINE    
The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance.
Juan Pablo Arroyo; Caroline Ronzaud; Dagmara Lagnaz; Olivier Staub; Gerardo Gamba
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Physiology (Bethesda, Md.)     Volume:  26     ISSN:  1548-9221     ISO Abbreviation:  Physiology (Bethesda)     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-13     Completed Date:  2011-08-10     Revised Date:  2011-11-28    
Medline Journal Info:
Nlm Unique ID:  101208185     Medline TA:  Physiology (Bethesda)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-23     Citation Subset:  IM    
Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.
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MeSH Terms
Aldosterone / physiology*
Ion Transport / physiology
Kidney Tubules, Distal / physiology*
Potassium / metabolism
Sodium Chloride / metabolism
Grant Support
Reg. No./Substance:
52-39-1/Aldosterone; 7440-09-7/Potassium; 7647-14-5/Sodium Chloride
Comment In:
Physiology (Bethesda). 2011 Oct;26(5):307; author reply 308   [PMID:  22013188 ]

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