Document Detail


Aldosterone, a new appreciation of its role in heart failure.
MedLine Citation:
PMID:  10999504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding of the role, triggers, and impact of the renin-angiotensin-aldosterone system in cardiovascular disease has significantly broadened. In recent years substantial discoveries have been made regarding the pathophysiology of heart failure, particularly in the area of neurohormonal activation. New interest in therapy with aldosterone antagonists was stimulated by results of a 2-year study of 1663 patients with heart failure that showed a 30% relative risk reduction of death among patients given a subhemodynamic dosage of spironolactone, a nonselective aldosterone antagonist, compared with placebo, in addition to standard therapy of diuretics, angiotensin-converting enzyme inhibitors, beta-blockers, and digitalis.
Authors:
A J Cha; S E Malecha; K W Judge
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  20     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-18     Completed Date:  2001-01-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1107-15     Citation Subset:  IM    
Affiliation:
Pharmacia Global Healthcare Resources, Skokie, Illinois 60077, USA.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / biosynthesis,  blood*
Aldosterone Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Heart Failure / drug therapy*,  physiopathology
Humans
Renin-Angiotensin System / physiology*
Spironolactone / therapeutic use*
Survival Analysis
Vasoconstriction / physiology
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 52-01-7/Spironolactone; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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