Document Detail

Aldosterone in uremia - beyond blood pressure.
MedLine Citation:
PMID:  20093814     Owner:  NLM     Status:  MEDLINE    
Aldosterone was in the past considered only as a prohypertensinogenic agent. It has recently become clear that apart from the classical endocrine action, i.e. causing blood pressure elevation as a result of salt retention, aldosterone has numerous blood-pressure-independent actions on nonepithelial tissue. Under conditions of high salt concentration, aldosterone is injurious to the kidney, heart and vasculature. Of particular interest are recent observations that aldosterone is a permissive factor for the effect of minor increases in plasma sodium concentration on endothelial cell dysfunction. Despite surprising effects of aldosterone blockade on blood pressure of anuric dialysis patients, the potential role of mineralocorticoid receptor blockade in dialysis patients is currently unclear and requires controlled investigation to define the risk of potential hazards, specifically hyperkalemia.
Eberhard Ritz; Nadezda Koleganova
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-01-08
Journal Detail:
Title:  Blood purification     Volume:  29     ISSN:  1421-9735     ISO Abbreviation:  Blood Purif.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-22     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  111-3     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Nierenzentrum, Ruperto Carola University Heidelberg, Heidelberg, Germany.
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MeSH Terms
11-beta-Hydroxysteroid Dehydrogenase Type 2 / physiology
Aldosterone / physiology*
Aldosterone Antagonists / adverse effects,  therapeutic use*
Endothelial Cells / drug effects
Endothelium, Vascular / physiopathology
Hydrocortisone / adverse effects,  physiology
Hyperaldosteronism / complications*,  drug therapy
Hyperkalemia / chemically induced
Hypertension / blood,  drug therapy,  etiology,  physiopathology*,  prevention & control
Metabolic Syndrome X / physiopathology
Receptors, Aldosterone / antagonists & inhibitors*,  chemistry,  physiology
Receptors, Mineralocorticoid / chemistry,  physiology
Renin-Angiotensin System / drug effects,  physiology
Sodium / blood
Sodium, Dietary / adverse effects*,  pharmacokinetics
Spironolactone / adverse effects,  therapeutic use
Uremia / blood,  physiopathology*
Vascular Resistance / drug effects,  physiology
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Receptors, Aldosterone; 0/Receptors, Mineralocorticoid; 0/Sodium, Dietary; 50-23-7/Hydrocortisone; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-23-5/Sodium; EC Dehydrogenase Type 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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