| Aldosterone in uremia - beyond blood pressure. | |
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MedLine Citation:
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PMID: 20093814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldosterone was in the past considered only as a prohypertensinogenic agent. It has recently become clear that apart from the classical endocrine action, i.e. causing blood pressure elevation as a result of salt retention, aldosterone has numerous blood-pressure-independent actions on nonepithelial tissue. Under conditions of high salt concentration, aldosterone is injurious to the kidney, heart and vasculature. Of particular interest are recent observations that aldosterone is a permissive factor for the effect of minor increases in plasma sodium concentration on endothelial cell dysfunction. Despite surprising effects of aldosterone blockade on blood pressure of anuric dialysis patients, the potential role of mineralocorticoid receptor blockade in dialysis patients is currently unclear and requires controlled investigation to define the risk of potential hazards, specifically hyperkalemia. |
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Authors:
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Eberhard Ritz; Nadezda Koleganova |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-08 |
Journal Detail:
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Title: Blood purification Volume: 29 ISSN: 1421-9735 ISO Abbreviation: Blood Purif. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-01-22 Completed Date: 2010-04-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
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Languages: eng Pagination: 111-3 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Nierenzentrum, Ruperto Carola University Heidelberg, Heidelberg, Germany. prof.e.ritz@t-online.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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11-beta-Hydroxysteroid Dehydrogenase Type 2
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physiology Aldosterone / physiology* Aldosterone Antagonists / adverse effects, therapeutic use* Endothelial Cells / drug effects Endothelium, Vascular / physiopathology Humans Hydrocortisone / adverse effects, physiology Hyperaldosteronism / complications*, drug therapy Hyperkalemia / chemically induced Hypertension / blood, drug therapy, etiology, physiopathology*, prevention & control Metabolic Syndrome X / physiopathology Receptors, Aldosterone / antagonists & inhibitors*, chemistry, physiology Receptors, Mineralocorticoid / chemistry, physiology Renin-Angiotensin System / drug effects, physiology Sodium / blood Sodium, Dietary / adverse effects*, pharmacokinetics Spironolactone / adverse effects, therapeutic use Uremia / blood, physiopathology* Vascular Resistance / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Receptors, Aldosterone; 0/Receptors, Mineralocorticoid; 0/Sodium, Dietary; 50-23-7/Hydrocortisone; 52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-23-5/Sodium; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenase Type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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