| Aldosterone and the heart. | |
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MedLine Citation:
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PMID: 10878752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport. Currently, there is excellent experimental evidence for aldosterone acting directly on the central nervous system to raise blood pressure, and on the heart to cause cardiac hypertrophy and fibrosis. In addition, there is emerging evidence for aldosterone synthesis in the heart, and for as yet unexplained benefits of aldosterone antagonism in the treatment of cardiac failure. |
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Authors:
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M Young; J W Funder |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 11 ISSN: 1043-2760 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2001-03-01 Completed Date: 2001-03-29 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 224-6 Citation Subset: IM |
Affiliation:
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Baker Medical Research Institute, PO Box 6492, St Kilda Road Central, Melbourne, Victoria 8008, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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biosynthesis,
blood,
genetics,
physiology* Animals Heart / physiology* Humans |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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