| Aldosterone and cardiovascular risk. | |
| | |
MedLine Citation:
|
PMID: 19895757 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Through its classic effects on sodium and potassium homeostasis, aldosterone, when produced in excess, is associated with the development of hypertension and hence with higher cardiovascular and renal risk. In recent years, experimental and epidemiologic data have suggested that aldosterone also may be linked to high cardiovascular risk independently of its effects on blood pressure. Thus, aldosterone has been associated with obesity and metabolic syndrome in selected populations, and these associations may further contribute to the higher cardiovascular risk of subjects with elevated aldosterone levels. Moreover, aldosterone has been reported to promote inflammation, oxidative stress, and fibrosis in a number of tissues. Clinical evidence indicates that patients with primary hyperaldosteronism have a higher risk of developing cardiovascular and renal complications than patients with essential hypertension who have the same level of blood pressure. Aldosterone receptor blockade has been shown to lower cardiovascular mortality after myocardial infarction and in patients with congestive heart failure. Some studies have also demonstrated that aldosterone blockade could have a favorable impact on the progression of renal disease. However, prospective interventional trials are needed to further evaluate the impact of blockade of aldosterone on cardiovascular risk. |
| | |
Authors:
|
Bruno Vogt; Michel Burnier |
Related Documents
:
|
2645767 - Clinical, biochemical, and hormonal changes after a single, large-volume paracentesis i... 323587 - Are there unknown mineralocorticoids in low-renin essential hypertension? 16864147 - Effects of raloxifene therapy on plasma renin and aldosterone levels and blood pressure... 2988827 - Blood pressure responses to acth and adrenaline infusions in dogs. 7199987 - Digital pulse volume in the evaluation of haemodynamic effects of cardiac pacing. 8583467 - Random zero sphygmomanometer versus automatic oscillometric blood pressure monitor; is ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current hypertension reports Volume: 11 ISSN: 1534-3111 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 450-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Recommendations for global hypertension monitoring and prevention.
Next Document: Direct Renin inhibition: an update.