| Aldosterone and cardiovascular remodelling: focus on myocardial failure. | |
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MedLine Citation:
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PMID: 15136967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure. |
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Authors:
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Frederick K Shieh; Eugene Kotlyar; Flora Sam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 5 ISSN: 1470-3203 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-05-11 Completed Date: 2004-10-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 3-13 Citation Subset: IM |
Affiliation:
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Boston University Medical School, Boston University Medical Center, Boston, Massechussetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism* Aldosterone Synthase / genetics Animals Blood Vessels / physiopathology Cardiac Output, Low / genetics, metabolism, physiopathology* Cardiovascular System / physiopathology* Humans Oxidative Stress Polymorphism, Genetic Ventricular Remodeling* |
| Grant Support | |
ID/Acronym/Agency:
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HL-04423/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 1.14.15.4/Aldosterone Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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