Document Detail

Aldosterone and cardiovascular remodelling: focus on myocardial failure.
MedLine Citation:
PMID:  15136967     Owner:  NLM     Status:  MEDLINE    
Heart failure is a clinical syndrome that may result from different disease states or conditions that injure the myocardium. The activation of circulating neurohormones, particularly aldosterone, may play a pivotal role in left ventricular (LV) remodelling. The Randomized Aldactone Evaluation Study and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival trial have emphasised the clinical importance of aldosterone. This review addresses some of the proposed mechanisms of LV remodelling in heart failure.
Frederick K Shieh; Eugene Kotlyar; Flora Sam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  5     ISSN:  1470-3203     ISO Abbreviation:  J Renin Angiotensin Aldosterone Syst     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-10-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-13     Citation Subset:  IM    
Boston University Medical School, Boston University Medical Center, Boston, Massechussetts, USA.
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MeSH Terms
Aldosterone / metabolism*
Aldosterone Synthase / genetics
Blood Vessels / physiopathology
Cardiac Output, Low / genetics,  metabolism,  physiopathology*
Cardiovascular System / physiopathology*
Oxidative Stress
Polymorphism, Genetic
Ventricular Remodeling*
Grant Support
Reg. No./Substance:
52-39-1/Aldosterone; EC Synthase

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