Document Detail

Aldosterone blunts the baroreflex response in man.
MedLine Citation:
PMID:  9831693     Owner:  NLM     Status:  MEDLINE    
1. Recent animal evidence suggests that aldosterone, like angiotensin II, may possess detrimental autonomic modulating properties. Aldosterone has been shown to impair the baroreflex response in animal models. This study is designed to test the hypothesis that aldosterone directly attenuates the baroreflex in vivo in man.2. Fourteen healthy male volunteers [mean age (S.D.) 25 (9) years] received intravenous d-aldosterone (12 and 5% dextrose (vehicle) in a double-blind crossover fashion, co-infused with incremental doses of intravenous phenylephrine and sodium nitroprusside. Aldosterone had no significant effect on resting blood pressure, heart rate or baroreflex response to sodium nitroprusside. However, reflex responses to phenylephrine were impaired with aldosterone (P<0.01) while blood pressure responses were unaltered. Baroreflex sensitivity was significantly blunted in the aldosterone group [8.36+/-2.19 versus 10.12+/-2.27 ms/mmHg; P<0. 04].3. This study confirms previous observations from animal models that aldosterone impairs the baroreflex response. High aldosterone levels may contribute to the baroreflex dysfunction in cardiovascular diseases such as hypertension and heart failure.
K M Yee; A D Struthers
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  95     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-26     Completed Date:  1999-01-26     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  687-92     Citation Subset:  IM    
University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, U.K.
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MeSH Terms
Aldosterone / pharmacology*
Baroreflex / drug effects*
Cross-Over Studies
Double-Blind Method
Heart Rate / drug effects
Hemodynamics / drug effects*
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 52-39-1/Aldosterone; 59-42-7/Phenylephrine
Comment In:
Clin Sci (Lond). 1998 Dec;95(6):647-8   [PMID:  9831688 ]

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