Document Detail

Aldosterone as an independent factor in cerebrovascular damage.
MedLine Citation:
PMID:  19021028     Owner:  NLM     Status:  MEDLINE    
Aldosterone is produced not only in the adrenal gland but also in other tissues, including the brain, where it plays an important role in the control of blood pressure and water and electrolyte homeostasis. Aldosterone has also been demonstrated to be a major factor in target organ damage independent of its effects on blood pressure. Herein we review the pathophysiology of aldosterone action in the brain and the clinical and experimental studies on the detrimental effects of aldosterone in the brain.
Paolo Mulatero; Mimma Caserta; Chiara Bertello; Domenica Schiavone; Andrea Verhovez; Giuseppe Giraudo; Fulvio Morello; Franco Veglio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  30     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  785-97     Citation Subset:  IM    
Division of Internal Medicine and Hypertension, Department of Medicine and Experimental Oncology, University of Torino, Torino, Italy.
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MeSH Terms
Aldosterone / adverse effects,  physiology*
Blood Pressure / physiology
Cerebrovascular Disorders / etiology,  physiopathology*
Disease Models, Animal
Hypertension / complications,  physiopathology*
Risk Factors
Stroke / etiology,  physiopathology
Reg. No./Substance:

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