| Aldosterone as a cardiovascular risk factor. | |
| | |
MedLine Citation:
|
PMID: 15808807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aldosterone exerts cardiovascular effects by influencing epithelial fluid and electrolyte excretion, and thus blood volume and pressure. Mineralocorticoid receptors (MR) are found in epithelial and non-epithelial tissues (vessel walls, heart, brain), with high affinity for aldosterone and physiological glucocorticoids cortisol and corticosterone. MR blockade by spironolactone or eplerenone favorably affects cardiovascular outcomes. In some situations (primary aldosteronism, experimental mineralocorticoid administration) activation of cardiovascular MR reflects aldosterone levels inappropriate for salt status. In others (heart failure, essential hypertension) aldosterone and Na(+) status are often normal pretreatment; cardiovascular MR may thus be activated by normal glucocorticoid levels after tissue damage and reactive oxygen species generation. Therefore, although unilateral adrenalectomy is preferred therapy for unilateral aldosterone-producing adenoma or hyperplasia, MR blockade may be useful in cardiovascular diseases where aldosterone levels are normal. |
| | |
Authors:
|
GianPaolo Rossi; Marco Boscaro; Vanessa Ronconi; John W Funder |
Related Documents
:
|
14736447 - Association between aldosterone synthase (cyp11b2) polymorphism and left ventricular ma... 1269097 - Relation between plasma renin activity, angiotensin, and aldosterone and blood pressure... 18698217 - Blood pressure outcome of adrenalectomy in patients with primary hyperaldosteronism wit... 7977727 - Effect of central amiloride infusion on mineralocorticoid hypertension. 19872507 - The respiration of luminous bacteria and the effect of oxygen tension upon oxygen consu... 17781567 - Compressibilities of lunar crystalline rock, microbreccia, and fines to 40 kilobars. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Trends in endocrinology and metabolism: TEM Volume: 16 ISSN: 1043-2760 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2005 Apr |
Date Detail:
|
Created Date: 2005-04-05 Completed Date: 2005-07-21 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 104-7 Citation Subset: IM |
Affiliation:
|
DMCS-Internal Medicine 4, University Hospital, via Giustiniani 2, 35126 Padua, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
metabolism* Animals Cardiac Output, Low / drug therapy Cardiovascular Diseases / etiology* Humans Hypertension / drug therapy Molecular Biology Receptors, Mineralocorticoid / antagonists & inhibitors Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Mineralocorticoid; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of diverse ion transport pathways by WNK4 kinase: a novel molecular switch.
Next Document: Low renin hypertensive states: perspectives, unsolved problems, future research.