Document Detail


Aldosterone and arterial hypertension.
MedLine Citation:
PMID:  20027193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the setting of primary aldosteronism, elevated aldosterone levels are associated with increased blood pressure. Aldosterone concentrations within the normal range, however, can also alter blood pressure. Furthermore, the aldosterone-to-renin ratio, an indicator of aldosterone excess, is associated with hypertension, even in patients without excessive absolute aldosterone levels. In this Review we assess the data on the role of aldosterone in the development and maintenance of hypertension. We provide an overview of the complex crosstalk between genetic and environmental factors, and about aldosterone-mediated arterial hypertension and target organ damage. The discussion is organized according to major targets of aldosterone action: the collecting duct in the kidney, the vasculature and the central nervous system. The antihypertensive efficacy of mineralocorticoid-receptor blockers, even in patients with aldosterone values in the normal range, supports the evidence that aldosterone plays a part in blood pressure elevation in the absence of primary aldosteronism.
Authors:
Andreas Tomaschitz; Stefan Pilz; Eberhard Ritz; Barbara Obermayer-Pietsch; Thomas R Pieber
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-12-22
Journal Detail:
Title:  Nature reviews. Endocrinology     Volume:  6     ISSN:  1759-5037     ISO Abbreviation:  Nat Rev Endocrinol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-25     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101500078     Medline TA:  Nat Rev Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Affiliation:
Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. andreas.tomaschitz@gmx.at
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MeSH Terms
Descriptor/Qualifier:
Aldosterone* / genetics,  pharmacology,  physiology
Aldosterone Synthase / genetics
Animals
Antihypertensive Agents
Blood Pressure
Blood Vessels / drug effects
Brain / drug effects
Ethnic Groups
Genetic Predisposition to Disease
Homeostasis
Humans
Hyperaldosteronism
Hypertension* / etiology,  genetics
Kidney Tubules, Collecting / drug effects
Receptors, Mineralocorticoid / antagonists & inhibitors
Renin / blood
Renin-Angiotensin System
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Receptors, Mineralocorticoid; 52-39-1/Aldosterone; EC 1.14.15.4/Aldosterone Synthase; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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