| Aldosterone and arterial hypertension. | |
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MedLine Citation:
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PMID: 20027193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the setting of primary aldosteronism, elevated aldosterone levels are associated with increased blood pressure. Aldosterone concentrations within the normal range, however, can also alter blood pressure. Furthermore, the aldosterone-to-renin ratio, an indicator of aldosterone excess, is associated with hypertension, even in patients without excessive absolute aldosterone levels. In this Review we assess the data on the role of aldosterone in the development and maintenance of hypertension. We provide an overview of the complex crosstalk between genetic and environmental factors, and about aldosterone-mediated arterial hypertension and target organ damage. The discussion is organized according to major targets of aldosterone action: the collecting duct in the kidney, the vasculature and the central nervous system. The antihypertensive efficacy of mineralocorticoid-receptor blockers, even in patients with aldosterone values in the normal range, supports the evidence that aldosterone plays a part in blood pressure elevation in the absence of primary aldosteronism. |
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Authors:
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Andreas Tomaschitz; Stefan Pilz; Eberhard Ritz; Barbara Obermayer-Pietsch; Thomas R Pieber |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-12-22 |
Journal Detail:
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Title: Nature reviews. Endocrinology Volume: 6 ISSN: 1759-5037 ISO Abbreviation: Nat Rev Endocrinol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500078 Medline TA: Nat Rev Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 83-93 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. andreas.tomaschitz@gmx.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone*
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genetics,
pharmacology,
physiology Aldosterone Synthase / genetics Animals Antihypertensive Agents Blood Pressure Blood Vessels / drug effects Brain / drug effects Ethnic Groups Genetic Predisposition to Disease Homeostasis Humans Hyperaldosteronism Hypertension* / etiology, genetics Kidney Tubules, Collecting / drug effects Receptors, Mineralocorticoid / antagonists & inhibitors Renin / blood Renin-Angiotensin System |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Receptors, Mineralocorticoid; 52-39-1/Aldosterone; EC 1.14.15.4/Aldosterone Synthase; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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