| Aldosterone and aldosterone antagonism in systemic hypertension. | |
| | |
MedLine Citation:
|
PMID: 15128471 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Aldosterone mediates both water and electrolyte balance by acting on the renal mineralocorticoid receptors. Recent experimental studies have also documented the presence of these receptors in other body organs, including the brain, blood vessels, and heart, suggesting that aldosterone plays a larger role in normal physiologic function and in cardiovascular diseases such as systemic hypertension and congestive heart failure (CHF). The nonspecific aldosterone inhibitor spironolactone, and the selective aldosterone inhibitor eplerenone, are both approved for clinical use in treating patients with hypertension and/or symptomatic CHF. Studies have shown that spironolactone lowers blood pressure, improves endothelial function, reduces myocardial hypertrophy and fibrosis, and lowers the incidence of fatal arrhythmias. Eplerenone, which is more specific for the mineralocorticoid receptor, appears to provide all the beneficial effects of spironolactone in hypertensive patients, with the potential to modify many of the side effects related to nonspecific steroid-receptor blockade. Hyperkalemia remains a potential problem with all aldosterone antagonists. |
| | |
Authors:
|
William H Frishman; Charles T Stier |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current hypertension reports Volume: 6 ISSN: 1522-6417 ISO Abbreviation: Curr. Hypertens. Rep. Publication Date: 2004 Jun |
Date Detail:
|
Created Date: 2004-05-06 Completed Date: 2004-09-28 Revised Date: 2006-07-12 |
Medline Journal Info:
|
Nlm Unique ID: 100888982 Medline TA: Curr Hypertens Rep Country: United States |
Other Details:
|
Languages: eng Pagination: 195-200 Citation Subset: IM |
Affiliation:
|
Department of Medicine, New York Medical College, Munger Pavilion 263, Valhalla, NY 10595, USA. William_Frishman@nymc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
physiology* Aldosterone Antagonists / administration & dosage, therapeutic use* Blood Pressure / drug effects Dose-Response Relationship, Drug Humans Hypertension / drug therapy*, physiopathology* Receptors, Aldosterone / antagonists & inhibitors, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Aldosterone Antagonists; 0/Receptors, Aldosterone; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pulse pressure, heart rate, and drug treatment of hypertension.
Next Document: Prevention of dementia and cerebroprotection with antihypertensive drugs.