| Aldosterone acts on the kidney, not the brain, to cause mineralocorticoid hypertension in sheep. | |
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MedLine Citation:
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PMID: 12023692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the extent to which mineralocortioid hypertension depends on a direct action of aldosterone on the kidney or on the brain. METHODS: Studies were performed in conscious sheep that were previously uninephrectomized, implanted with silastic cannulae in the renal artery of the remaining kidney, and had guide tubes implanted over the lateral cerebral ventricles. The effect of aldosterone, infused either intrarenally (i.r.; 2 microg/h) or intravenously (i.v.; 2 and 10 microg/h) for 10 days (n = 5), on arterial pressure and fluid and electrolyte balance was determined. The i.r. (2 microg/h) and i.v. (10 microg/h) doses were calculated to give similar intrarenal concentrations of aldosterone. In a further study, the effect of intracerebroventricular (i.c.v.) infusion of aldosterone (2 microg/h for 21 days) on arterial pressure was examined (n = 5). RESULTS: Infusion of aldosterone caused a progressive increase in mean arterial pressure from 83 +/- 3 mmHg to a maximum of 100 +/- 4 mmHg (P < 0.001) with 2 microg/h i.r. and from 84 +/- 3 mmHg to a maximum of 104 +/- 4 mmHg (P < 0.001) with 10 microg/h i.v., both by day 7. With both infusions there were similar increases in plasma [Na+] and decreases in plasma [K+] and total protein concentration (P < 0.05) between days 3 and 5; these were maintained throughout the infusion. There were no significant changes with i.v. aldosterone (2 microg/h). Long-term i.c.v. infusion of aldosterone (2 microg/h for 21 days) caused no change in arterial pressure. CONCLUSIONS: In conscious sheep the hypertensive response to aldosterone resulted from an action on the kidney, with no evidence for a direct action on the brain. |
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Authors:
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Leopoldo A Sosa Le?n; Michael J McKinley; Robin M McAllen; Clive N May |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 20 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-05-22 Completed Date: 2002-12-04 Revised Date: 2010-03-23 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1203-8 Citation Subset: IM |
Affiliation:
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Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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administration & dosage,
pharmacology* Animals Blood / metabolism Blood Pressure / drug effects Body Fluids / metabolism Brain / drug effects Electrolytes / metabolism Female Hormones / blood Hypertension / chemically induced*, metabolism, physiopathology Infusions, Intravenous Injections Injections, Intraventricular Kidney / drug effects* Mineralocorticoids* Sheep Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Hormones; 0/Mineralocorticoids; 52-39-1/Aldosterone |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2002 Jun;20(6):1079-80
[PMID:
12023673
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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