| Aldosterone production and insulin resistance in healthy adults. | |
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MedLine Citation:
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PMID: 20130077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Aldosterone production is associated with insulin resistance in obese and hypertensive subjects. However, its effect on insulin sensitivity in healthy subjects is not clear. OBJECTIVE: The objective of this study was to test the hypothesis that increased aldosterone production is associated with lower insulin sensitivity in healthy subjects. DESIGN: This is an analysis of data previously collected during studies conducted as part of the International Hypertensive Pathotype Consortium. Participants and Interventions: Eighty-four subjects free of any medical or psychiatric illness were included in this study. They were studied after 7 d of a standardized high-sodium diet confirmed by 24-h urine sodium above 200 mEq. Insulin sensitivity index (ISI) was calculated after a 75-g oral glucose load with glucose and insulin measurements at 0, 30, 60, and 120 min. Serum aldosterone levels were measured after 45 min of angiotensin II (3 ng/kg/min) infusion. RESULTS: There were significant negative correlations between ISI and age, body mass index (BMI), diastolic blood pressure, and angiotensin II-stimulated aldosterone level (P < 0.01). On multivariate regression analysis, stimulated aldosterone level was an independent predictor of ISI after adjusting for age, BMI, and diastolic blood pressure. Stimulated aldosterone level predicted 8% of the variance in ISI (P = 0.003) with age, BMI, and diastolic blood pressure together predicting 23% of the variance in ISI. Thus, the final regression model predicted 31% of the variance in ISI (P < 0.0001). CONCLUSIONS: Aldosterone production is associated with insulin resistance in normotensive healthy subjects independent of traditional risk factors. |
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Authors:
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Rajesh Garg; Shelley Hurwitz; Gordon H Williams; Paul N Hopkins; Gail K Adler |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-03 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-04-30 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1986-90 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA. rgarg@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aging / physiology Aldosterone / biosynthesis* Angiotensin II / pharmacology Blood Pressure Body Mass Index Female Humans Insulin Resistance / physiology* Male Middle Aged Predictive Value of Tests Reference Values Sex Characteristics Stimulation, Chemical Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DK63214/DK/NIDDK NIH HHS; HL087060/HL/NHLBI NIH HHS; HL47651/HL/NHLBI NIH HHS; HL59424/HL/NHLBI NIH HHS; M01RR00064/RR/NCRR NIH HHS; M01RR00095/RR/NCRR NIH HHS; M01RR02635/RR/NCRR NIH HHS; P50HL055000/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 52-39-1/Aldosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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