Document Detail


Aldosterone and the Heart: From Basic Research to Clinical Evidence.
MedLine Citation:
PMID:  22095099     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent views suggest that long-term exposure to elevated aldosterone concentrations might result in cardiac, vascular, renal, and metabolic sequelae that occur independent of the blood pressure level. Indirect evidence of the untoward effects of aldosterone on the heart has been clearly established in clinical studies that have tested the effects of mineralocorticoid receptor antagonists in the treatment of systolic heart failure. As it has become clear in recent years, the interaction between aldosterone and the heart has to deal with additional actions of the hormone on specific cell types, cellular mechanisms, and molecules that are involved in regulation of tissue responses, leading to hypertrophy, remodeling, and fibrosis. The majority of these effects are mediated by activation of the mineralocorticoid receptors that are expressed in cardiomyocytes and cardiac fibroblasts, and mediate the genomic effects of the hormone. Evidence of interactions between aldosterone and the heart that occur independent of the renal effects of aldosterone, however, is not limited to the context of systolic heart failure and observations obtained in other disease states have led, together with findings of animal studies, to a better understanding of the potential benefits of aldosterone antagonists. In this narrative overview, we highlight the most recent findings that have been obtained in experimental animal models and in clinical conditions that include, in addition to systolic heart failure, primary aldosteronism, essential hypertension, diastolic heart failure, and arrhythmia.
Authors:
C Catena; G Colussi; L Marzano; L A Sechi
Related Documents :
758769 - Differential accumulation of radiopaque contrast material in acute myocardial infarction.
1260989 - Effect of intra-aortic balloon counterpulsation on the motion and perfusion of acutely ...
22830029 - A model of left ventricular dysfunction complicated by caws arteritis in dba/2 mice.
22695389 - The effect of revascularization procedures on myocardial infarction incidence rates and...
22537739 - Ultrafine carbon black disturbs heart rate variability in mice.
15227059 - Determinants of infarct size in patients successfully treated by intracoronary thrombol...
23994209 - Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infar...
5567769 - Long-term ventricular pacing in treatment of sinoatrial block.
9287229 - Stent placement compared with balloon angioplasty for obstructed coronary bypass grafts...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-17
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme     Volume:  -     ISSN:  1439-4286     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Association of cognitive function and risk for elder abuse in a community-dwelling population.
Next Document:  Salivary transcriptomic biomarkers for detection of ovarian cancer: for serous papillary adenocarcin...