| Aldheides monoterpenes as potential anti-Leishmania agents: Activity of Cymbopongon citratus and citral on L. infantum, L. tropica and L. major. | |
| | |
MedLine Citation:
|
PMID: 22227102 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In order to contribute for the search of new drugs for leishmaniasis, we study the susceptibility of Leishmania infantum, Leishmania tropica and Leishmania major to Cymbopogon citratus essential oil and major compounds, mrycene and citral. C. citratus and citral were the most active inhibiting L. infantum, L. tropica and L. major growth at IC(50) concentrations ranging from 25 to 52μg/ml and from 34 to 42μg/ml, respectively. L. infantum promastigotes exposed to essential oil and citral underwent considerable ultrastructural alterations, namely mitochondrial and kinetoplast swelling, autophagosomal structures, disruption of nuclear membrane and nuclear chromatin condensation. C. citratus essential oil and citral promoted the leishmanicidal effect by triggering a programmed cell death. In fact, the leishmanicidal activity was mediated via apoptosis as evidenced by externalization of phosphatidylserine, loss of mitochondrial membrane potential, and cell-cycle arrest at the G(0)/G(1) phase. Taken together, ours findings lead us to propose that citral was responsible for anti-Leishmania activity of the C. citratus and both may represent a valuable source for therapeutic control of leishmaniasis. |
| | |
Authors:
|
M Machado; P Pires; A M Dinis; M Santos-Rosa; V Alves; L Salgueiro; C Cavaleiro; M C Sousa |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-2 |
Journal Detail:
|
Title: Experimental parasitology Volume: - ISSN: 1090-2449 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370713 Medline TA: Exp Parasitol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Faculdade de Farmácia/CEF, Universidade de Coimbra, Azinhaga de Santa Comba, 3030-548 Coimbra, Portugal; Departamento Farmácia, Escola Superior de Saúde do Vale do Ave/Centro de Investigação em Tecnologias da Saúde IPSN-CESPU, 4760 Vila Nova de Famalicão, Portugal. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ephrin-B2 and ephrin-B3 as functional henipavirus receptors.
Next Document: Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenom...