| Alcoholism and the Armanni-Ebstein lesion. | |
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MedLine Citation:
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PMID: 21805374 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The Armanni-Ebstein lesion is a histological change in the kidney consisting of sub-nuclear vacuolation of the proximal tubules. It has been most associated with diabetic ketoacidosis. The vacuoles have been reported to contain glycogen. More recent studies show them to contain fat. Recent papers have associated the Armanni-Ebstein lesion with non-diabetic ketoacidosis. We present 11 cases of alcoholic ketoacidosis where the Armanni-Ebstein lesion was identified. None had a history of diabetes mellitus and none showed any changes of diabetic nephropathy. All 11 cases had raised acetone levels (3-67 mg/100 mL (mean 17.9 mg/100 mL and median value of 16 mg/100 mL). In addition a case of isopropanol poisoning was found to have the Armanni-Ebstein lesion. Isopropanol is converted to acetone but is not associated with acidosis. These results indicate that the Armanni-Ebstein lesion is not specific to diabetes mellitus. |
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Authors:
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Jacqueline L Parai; Sarathchandra Kodikara; Christopher M Milroy; Michael S Pollanen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-31 |
Journal Detail:
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Title: Forensic science, medicine, and pathology Volume: - ISSN: 1556-2891 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236111 Medline TA: Forensic Sci Med Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Anatomical Pathology, Eastern Ontario Forensic Pathology Unit, Ontario Forensic Pathology Service, The Ottawa Hospital, 501 Smyth Road, Ottawa, ON, K1H8L6, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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