| Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. | |
| | |
MedLine Citation:
|
PMID: 12838517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Characteristics of alcoholic neuropathy have been obscured by difficulty in isolating them from features of thiamine-deficiency neuropathy. We assessed 64 patients with alcoholic neuropathy including subgroups without (ALN) and with (ALN-TD) coexisting thiamine deficiency. Thirty-two patients with nonalcoholic thiamine-deficiency neuropathy (TDN) also were investigated for comparison. In ALN, clinical symptoms were sensory-dominant and slowly progressive, predominantly impairing superficial sensation (especially nociception) with pain or painful burning sensation. In TDN, most cases manifested a motor-dominant and acutely progressive pattern, with impairment of both superficial and deep sensation. Small-fiber-predominant axonal loss in sural nerve specimens was characteristic of ALN, especially with a short history of neuropathy; long history was associated with regenerating small fibers. Large-fiber-predominant axonal loss predominated in TDN. Subperineurial edema was more prominent in TDN, whereas segmental de/remyelination resulting from widening of consecutive nodes of Ranvier was more frequent in ALN. Myelin irregularity was greater in ALN. ALN-TD showed a variable mixture of these features in ALN and TDN. We concluded that pure-form of alcoholic neuropathy (ALN) was distinct from pure-form of thiamine-deficiency neuropathy (TDN), supporting the view that alcoholic neuropathy can be caused by direct toxic effect of ethanol or its metabolites. However, features of alcoholic neuropathy is influenced by concomitant thiamine-deficiency state, having so far caused the obscure clinicopathological entity of alcoholic neuropathy. |
| | |
Authors:
|
Haruki Koike; Masahiro Iijima; Makoto Sugiura; Keiko Mori; Naoki Hattori; Hiroki Ito; Masaaki Hirayama; Gen Sobue |
Related Documents
:
|
7131047 - Differentiation of the nodal and internodal axolemma in the optic nerves of neonatal rats. 2083877 - Study of innervation of the pancreatic duct of lepus europaeus, using the cholinesteras... 23059557 - Myogenin, myod and igf-i regulate muscle mass but not fiber-type conversion during resi... 55467 - Dynamic aspects of peripheral nerve changes in progressive neural muscular atrophy: lig... 21888527 - Forearm muscle size, strength, force, and power in relation to pqct-derived bone streng... 2403277 - Maximal isometric torque of knee extension as a function of muscle length in subjects o... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of neurology Volume: 54 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2003 Jul |
Date Detail:
|
Created Date: 2003-07-02 Completed Date: 2003-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 19-29 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Nagoya University, Graduate School of Medicine, Nagoya, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Alcoholic Neuropathy / chemically induced, complications, diagnosis* Axons / pathology Biopsy Ethanol / adverse effects Female Humans Male Median Nerve / pathology, physiopathology Middle Aged Muscle, Skeletal / innervation, physiopathology Myelin Sheath / pathology Nerve Fibers / pathology Nociceptors / physiology Pain / complications Ranvier's Nodes / pathology Sural Nerve / pathology, physiopathology Thiamine Deficiency / complications, diagnosis*, physiopathology* Tibial Nerve / pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
|
64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hereditary motor and sensory neuropathy with agenesis of the corpus callosum.
Next Document: Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations.