Document Detail


Alcoholic cirrhosis-associated hepatorenal syndrome treated with vasoactive agents.
MedLine Citation:
PMID:  16932415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A 35-year-old man with alcoholic cirrhosis, ascites and alcoholic hepatitis presented with new-onset renal insufficiency of unclear etiology after recovery from an episode of gastrointestinal bleeding. Renal function continued to worsen after cessation of diuretic therapy and initiation of volume resuscitation. INVESTIGATIONS: Physical examination, abdominal ultrasound, liver tests, basic metabolic panel, abdominal paracentesis, renal function tests, 24-h urine collections. DIAGNOSIS: Type 1 hepatorenal syndrome (HRS). MANAGEMENT: Intravascular volume resuscitation with normal saline and albumin followed by oral midodrine plus subcutaneous octreotide therapy. This regimen was continued until improvement and subsequent normalization of the serum creatinine.
Authors:
Eric Esrailian; Bruce A Runyon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nature clinical practice. Nephrology     Volume:  2     ISSN:  1745-8323     ISO Abbreviation:  -     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101261800     Medline TA:  Nat Clin Pract Nephrol     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Affiliation:
Center for Health Sciences and the David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Albumins / therapeutic use
Gastrointestinal Hemorrhage / complications
Hepatitis, Alcoholic / complications
Humans
Isotonic Solutions / therapeutic use
Liver Cirrhosis, Alcoholic / complications*
Male
Midodrine / therapeutic use*
Renal Insufficiency, Acute / drug therapy*,  etiology*
Sodium Chloride / therapeutic use
Vasoconstrictor Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Albumins; 0/Isotonic Solutions; 0/Vasoconstrictor Agents; 42794-76-3/Midodrine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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