Document Detail

Alcoholic cirrhosis-associated hepatorenal syndrome treated with vasoactive agents.
MedLine Citation:
PMID:  16932415     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A 35-year-old man with alcoholic cirrhosis, ascites and alcoholic hepatitis presented with new-onset renal insufficiency of unclear etiology after recovery from an episode of gastrointestinal bleeding. Renal function continued to worsen after cessation of diuretic therapy and initiation of volume resuscitation. INVESTIGATIONS: Physical examination, abdominal ultrasound, liver tests, basic metabolic panel, abdominal paracentesis, renal function tests, 24-h urine collections. DIAGNOSIS: Type 1 hepatorenal syndrome (HRS). MANAGEMENT: Intravascular volume resuscitation with normal saline and albumin followed by oral midodrine plus subcutaneous octreotide therapy. This regimen was continued until improvement and subsequent normalization of the serum creatinine.
Eric Esrailian; Bruce A Runyon
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nature clinical practice. Nephrology     Volume:  2     ISSN:  1745-8323     ISO Abbreviation:  -     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101261800     Medline TA:  Nat Clin Pract Nephrol     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-72     Citation Subset:  IM    
Center for Health Sciences and the David Geffen School of Medicine at University of California, Los Angeles, CA, USA.
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MeSH Terms
Albumins / therapeutic use
Gastrointestinal Hemorrhage / complications
Hepatitis, Alcoholic / complications
Isotonic Solutions / therapeutic use
Liver Cirrhosis, Alcoholic / complications*
Midodrine / therapeutic use*
Renal Insufficiency, Acute / drug therapy*,  etiology*
Sodium Chloride / therapeutic use
Vasoconstrictor Agents / therapeutic use*
Reg. No./Substance:
0/Albumins; 0/Isotonic Solutions; 0/Vasoconstrictor Agents; 42794-76-3/Midodrine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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