| Alcoholic liver disease-related mortality in the United States: 1980-2003. | |
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MedLine Citation:
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PMID: 20179691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Data on temporal changes in alcoholic liver disease (ALD)-related mortality in the United States are lacking. This longitudinal assessment is important, given the divergent data on trends in worldwide ALD-related mortality, concerns for underestimation of mortality attributed to ALD in previous investigations, and shifting attention to hepatitis C virus (HCV)-related mortality. METHODS: We analyzed mortality data compiled in the multiple cause-of-death public-use data file from the National Vital Statistics System from 1980 to 2003 using categorization by both International Classification of Diseases (ICD)-9 and ICD-10 systems. The main outcome measure was age- and sex-adjusted death rates attributable to ALD, HCV, or both (ALD/HCV) listed as immediate or underlying cause of death. RESULTS: A total of 287,365 deaths were observed over the 24-year period. Age- and sex- adjusted incidence rates of ALD-related deaths decreased from 6.9/100,000 persons in 1980 to 4.4/100,000 persons by 2003. After introduction of HCV diagnostic testing, HCV-related liver mortality increased to 2.9/100,000 persons by 2003. Death rates for subjects with concomitant ALD/HCV rose to 0.2/100,000 persons by 1999 and then remained unchanged through 2003. Age-specific mortality related to ALD was highest in the ages of 45-64 years. Between 1980 and 2003, the age- and sex-adjusted ALD-related mortality (per 100,000 persons) decreased from 6.3 to 4.5 among Caucasians, 11.6 to 4.1 among African Americans, and 8.0 to 3.7 among the "other" race group. CONCLUSIONS: Despite a decline in ALD-related mortality, the proportion of alcohol-related liver deaths is still considerably large and comparable in scope to that of HCV. |
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Authors:
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Helga Paula; Sumeet K Asrani; Nicholas C Boetticher; Rachel Pedersen; Vijay H Shah; W Ray Kim |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-02-23 |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 105 ISSN: 1572-0241 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2010-09-14 Revised Date: 2011-05-06 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 1782-7 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cause of Death Female Hepatitis C / ethnology, mortality Humans International Classification of Diseases Liver Diseases, Alcoholic / ethnology, mortality* Male Middle Aged United States / epidemiology Vital Statistics |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK034238-23/DK/NIDDK NIH HHS; R01 DK059615/DK/NIDDK NIH HHS; R01 DK059615-07/DK/NIDDK NIH HHS; R01DK-34238/DK/NIDDK NIH HHS; T32 DK007198-35/DK/NIDDK NIH HHS; T32 DK07198/DK/NIDDK NIH HHS |
| Comments/Corrections | |
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