Document Detail


Alcoholic and cocaine-associated cardiomyopathies.
MedLine Citation:
PMID:  20109599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol and cocaine use are associated with significant cardiovascular complications, including cardiomyopathy. The pathophysiologic mechanisms underlying the development of these toxic cardiomyopathies vary depending on the inciting agent but include direct toxic effects, neurohormonal activation, altered calcium homeostasis, and oxidative stress. The typical patient with alcoholic cardiomyopathy is a long-term excessive alcohol consumer who is otherwise indistinguishable from other patients with nonischemic cardiomyopathy. The typical patient with cocaine cardiomyopathy is a young male smoker who presents with signs of adrenergic excess. Management of these patients is similar to that of patients with other forms of dilated cardiomyopathy, although beta-blockers should be avoided in patients with cocaine-associated heart failure and benzodiazepines should be given in this setting to blunt adrenergic excess. Left ventricular function may improve dramatically with abstinence from alcohol or cocaine. Unfortunately, the rate of recidivism is high and left ventricular dysfunction and symptomatic heart failure often recurs.
Authors:
Eric H Awtry; George J Philippides
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  52     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-02-22     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  289-99     Citation Subset:  AIM; IM    
Affiliation:
Cardiovascular Section Boston Medical Center, Boston, MA 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcoholism / complications*
Animals
Cardiomyopathies / diagnosis,  etiology*,  therapy
Cocaine-Related Disorders / complications*
Disease Progression
Female
Heart Failure / diagnosis,  etiology*,  therapy
Humans
Male
Middle Aged
Recurrence
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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