Document Detail

Alcohol withdrawal syndromes: clinical management with lofexidine.
MedLine Citation:
PMID:  3890587     Owner:  NLM     Status:  MEDLINE    
Sixty-three mainly male alcoholics were randomly assigned to placebo or lofexidine treatment for 48 hr shortly after admission to the hospital. Their starting points were similar regarding their semiquantitative estimates of alcohol withdrawal symptoms (AWS). Their demographics, histories of past alcohol use, physical findings, and laboratory abnormalities usually associated with alcoholism were similar. Starting 3 hr after 0.4 mg of oral lofexidine, which was given every 6 hr as eight doses, the AWS scores were significantly lower than those of the placebo group. Hypotension was the strongest finding. Six placebo recipients had to be prematurely interrupted due to increasing or intolerable alcohol withdrawal symptoms and switched to a benzodiazepine. Only one lofexidine recipient was prematurely interrupted, due to transient hallucinations. The study has a large placebo effect, as both groups of patients rated the treatment process very highly. Lofexidine, an alpha 2-adrenergic agonist, was superior to placebo in alcohol withdrawal. This drug, as with its analogue clonidine, may represent a new and important pharmacological treatment for alcohol withdrawal symptoms.
P Cushman; R Forbes; W Lerner; M Stewart
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  9     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:    1985 Mar-Apr
Date Detail:
Created Date:  1985-06-27     Completed Date:  1985-06-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Clonidine / adverse effects,  analogs & derivatives*,  therapeutic use
Double-Blind Method
Ethanol / adverse effects*
Hypotension / chemically induced
Middle Aged
Patient Compliance
Random Allocation
Seizures / chemically induced
Substance Withdrawal Syndrome / drug therapy*
Reg. No./Substance:
31036-80-3/lofexidine; 4205-90-7/Clonidine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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