| Alcohol tolerance in Escherichia coli. | |
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MedLine Citation:
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PMID: 7017759 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During growth with ethanol, the proportion of 18:1 fatty acid in the lipids of E. coli increases at the expense of saturated fatty acids. The significance of these changes was investigated in terms of growth and survival in the presence of ethanol. Two approaches were used: (1) A comparison of alcohol tolerance among strains of E. coli with different fatty acid compositions; (2) A comparison of alcohol tolerance using a lipid mutant in which the fatty acid composition was controlled by exogenous supplements. An increase in unsaturated fatty acid content was beneficial for both growth and survival. We conclude that the alcohol-induced changes in the fatty acid composition of E. coli are part of an adaptive response, compensating for some of the harmful effects of this drug. |
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Authors:
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L O Ingram; N S Vreeland; L C Eaton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 13 Suppl 1 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1980 |
Date Detail:
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Created Date: 1981-08-10 Completed Date: 1981-08-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane
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drug effects Drug Resistance, Microbial Escherichia coli / drug effects*, metabolism Ethanol / pharmacology* Fatty Acids / metabolism Lipid Metabolism Membrane Fluidity |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 AA 3816-01/AA/NIAAA NIH HHS; 1 R01 GM 24059-19/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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