Document Detail


Alcohol, tobacco and marijuana use among pregnant teenagers: 6-year follow-up of offspring growth effects.
MedLine Citation:
PMID:  12460652     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This prospective study evaluated the relations between maternal alcohol, tobacco and marijuana use during pregnancy and children's growth at 6 years. In this cohort of pregnant teenagers and their offspring, mothers were recruited from an urban prenatal clinic between 1990 and 1995, and observed from their fourth prenatal month. At the delivery assessment, there were 413 live-born singletons. At the 6-year visit, 345 children and mothers were evaluated. Prenatal alcohol and marijuana exposure were significantly associated with growth deficits, after controlling statistically for other prenatal substance use, current maternal substance use, current environmental tobacco exposure (ETS) and sociodemographic and growth-related covariates. There was a significant negative association between the second and third trimester alcohol exposure and offspring height. Third trimester alcohol exposure predicted reduced skinfold thickness. Exposure to any prenatal marijuana in the second trimester was significantly associated with shorter stature. First trimester tobacco exposure was associated with increased skinfold thickness among the 6-year-olds. The effects of prenatal alcohol exposure on growth at birth persisted in older children despite a low level of exposure during gestation. Effects of prenatal marijuana exposure on reduced height were not anticipated and occurred only when use was categorized as any/none. These data are consistent with an emerging body of evidence indicating that, by contrast to the growth deficits associated with smoking during pregnancy, which are evident at birth, the shorter stature associated with prenatal alcohol exposure continues to be evident during childhood.
Authors:
Marie D Cornelius; Lidush Goldschmidt; Nancy L Day; Cynthia Larkby
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  24     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-12-03     Completed Date:  2003-03-12     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-10     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Building, PA 15213, USA. mdc1@pitt.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group
Age Factors
Alcoholism / complications*
Body Weight / drug effects,  physiology
Child
Educational Status
European Continental Ancestry Group
Failure to Thrive / chemically induced*,  epidemiology,  physiopathology
Female
Fetal Alcohol Syndrome / epidemiology*,  pathology,  physiopathology
Fetal Growth Retardation / chemically induced*,  epidemiology,  physiopathology
Follow-Up Studies
Humans
Male
Marijuana Abuse / complications*
Marital Status
Pregnancy
Prenatal Exposure Delayed Effects*
Prospective Studies
Tobacco Use Disorder / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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