Document Detail


Alcohol and the risk of myocardial infarction.
MedLine Citation:
PMID:  11327330     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effect of alcohol consumption independent from the specific kind of alcoholic beverage, there is increasing evidence that wine and in particular red wine might contain pharmacological substances, which prevent atherosclerosis and myocardial infarction independent from the wine ethanol. Pathophysiological mechanisms mediating these beneficial effects include effects of wine phenols and tannins on LDL-cholesterol oxidation status, thrombocyte aggregation, endothelial function and smooth muscle cell proliferation. Identification and characterization of the pharmacologically active substances might provide the stage for the development of new substances to be used in the prevention of coronary artery disease and myocardial infarction.
Authors:
M Flesch; S Rosenkranz; E Erdmann; M Böhm
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Basic research in cardiology     Volume:  96     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-30     Completed Date:  2001-08-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  128-35     Citation Subset:  IM    
Affiliation:
Klinik III für Innere Medizin der Universität zu Köln, Germany. markus.flesch@medizin.uni-koeln.de
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking*
Humans
Myocardial Infarction / epidemiology,  prevention & control*
Risk Factors
Wine*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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