| Alcohol and risk of breast cancer in Mexican women. | |
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MedLine Citation:
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PMID: 20155314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Little is known about the relationship between alcohol intake and breast cancer risk among Mexican women. This association may be modified by folate and Vitamin B12. METHODS: A population-based case-control study conducted in Mexico recruited 1,000 incident breast cancer cases aged 35-69 and 1,074 controls matched on age, region, and health care system. In-person interviews were conducted to assess breast cancer risk factors and recent diet using a food frequency questionnaire. Conditional logistic regression models estimated adjusted odds ratios and 95% confidence intervals. RESULTS: Over one-half (57%) of cases and less than one-half of controls (45%) reported any lifetime alcohol consumption. Compared with never drinkers, women reporting ever drinking (Adjusted OR = 1.25, 95% CI = 0.99-1.58) had a greater odds of breast cancer. There was evidence for interaction in the association between ever consuming any alcohol and breast cancer by folate (p for interaction = 0.04) suggesting women with lower folate intake had a higher odds of breast cancer (Adjusted OR = 1.99, 95% CI = 1.26-3.16) compared to women with higher folate intake (OR = 1.12, 95% CI = 0.69-1.83). CONCLUSIONS: Our findings support evidence that any alcohol intake increases risk of breast cancer. Insufficient intake of folate may further elevate risk for developing breast cancer among women who consume alcohol. |
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Authors:
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Jeannette M Beasley; Gloria D Coronado; Jennifer Livaudais; Angélica Angeles-Llerenas; Carolina Ortega-Olvera; Isabelle Romieu; Eduardo Lazcano-Ponce; Gabriela Torres-Mejía |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-02-13 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 21 ISSN: 1573-7225 ISO Abbreviation: Cancer Causes Control Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-20 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: Netherlands |
Other Details:
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Languages: eng Pagination: 863-70 Citation Subset: IM |
Affiliation:
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Group Health Research Institute, 1730 Minor Avenue Suite 1600, Seattle, WA, 98101, USA. jbeasley@fhcrc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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adverse effects* Breast Neoplasms / etiology Case-Control Studies Confidence Intervals Diet Ethanol Female Folic Acid Humans Logistic Models Mexican Americans Mexico / epidemiology Neoplasm Staging Odds Ratio Questionnaires Risk Factors Vitamin B 12 |
| Grant Support | |
ID/Acronym/Agency:
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1U54CA13238/CA/NCI NIH HHS; U54 CA132381-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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59-30-3/Folic Acid; 64-17-5/Ethanol; 68-19-9/Vitamin B 12 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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