| Alcohol-related sudden death with hepatic fatty metamorphosis: a comprehensive clinicopathological inquiry into its pathogenesis. | |
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MedLine Citation:
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PMID: 9463729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To clarify the pathogenesis of the widely known but obscure syndrome of sudden death with hepatic fatty metamorphosis observed in alcohol abusers, we have scrutinized both the clinical and pathological data of 11 subjects who died under such circumstances between 1987 and 1993. Death followed several days of uninterrupted drinking often with little dietary intake. The notable clinical features on arrival at the emergency room were disturbance of consciousness (11/11), hypotension (4/6), hypothermia (3/5), hypoglycaemia (8/11), metabolic acidosis (6/6), renal dysfunction (11/11), and hyperammonaemia (5/5). The common hepatic pathology was the extensive appearance of numerous microvesicular fatty droplets in the hepatocytes together with varying degrees of macrovesicular fatty change; four subjects had an underlying cirrhosis. Death undoubtedly results from a variety of metabolic disturbances triggered by the combination of massive ethanol intake and starvation. The appearance of extensive microvesicular fatty change superimposed on macrovesicular fatty change was considered to be an associated phenomenon. |
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Authors:
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T Yuzuriha; M Okudaira; I Tominaga; S Hori; H Suzuki; Y Matsuo; M Shoji; A Yokoyama; S Takagi; M Hayashida |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Alcohol and alcoholism (Oxford, Oxfordshire) Volume: 32 ISSN: 0735-0414 ISO Abbreviation: Alcohol Alcohol. Publication Date: 1997 Nov-Dec |
Date Detail:
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Created Date: 1998-04-03 Completed Date: 1998-04-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310684 Medline TA: Alcohol Alcohol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 745-52 Citation Subset: IM |
Affiliation:
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National Institute on Alcoholism, Kurihama National Hospital, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Death, Sudden / etiology* Ethanol / blood Fatty Liver, Alcoholic / complications*, pathology*, physiopathology Female Humans Laboratory Techniques and Procedures Liver / pathology Liver Circulation / physiology Male Microcirculation / pathology Middle Aged |
| Chemical | |
Reg. No./Substance:
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64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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