Document Detail


Alcohol-related birth defects in long- and short-sleep mice: postnatal litter mortality.
MedLine Citation:
PMID:  2261084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alcohol sensitivity may influence the severity of alcohol-related birth defects (ARBD). To examine this hypothesis, pregnancy outcome and offspring development were examined in alcohol-sensitive Long-Sleep (LS) mice and alcohol-resistant Short-Sleep (SS) mice following prenatal ethanol exposure. Dams were intragastrically intubated twice per day (6 hr apart) with either 4.5 g/kg (20% w/v) ethanol (E) or an isocaloric amount of sucrose (S) on days 7 through 18 of pregnancy. An untreated control group (C) was maintained for each line. Results showed litter mortality at 10 days of age was greater for LS-E litters compared to both LS-S and LS-C litters. Litter mortality for SS-E litters did not differ from either SS-S or SS-C litters. Maternal weight gain, blood ethanol levels, and birth weight deficits were similar for ethanol-exposed LS and SS groups. These results suggest genetically based alcohol sensitivity influences the severity of ARBD.
Authors:
D M Gilliam; L E Kotch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  7     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:    1990 Nov-Dec
Date Detail:
Created Date:  1991-02-04     Completed Date:  1991-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-7     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Northern Colorado, Greeley 80639.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced*
Animals
Birth Weight / drug effects
Body Weight / drug effects
Ethanol / blood,  toxicity*
Female
Fetus / drug effects*
Litter Size / drug effects
Male
Mice
Mortality
Pregnancy
Pregnancy Outcome
Sleep
Grant Support
ID/Acronym/Agency:
AA06939/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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