| Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system. | |
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MedLine Citation:
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PMID: 18789935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to investigate the effect of alcohol and nicotine consumption on the pathogenesis of choroidal neovascularization (CNV) in rats after laser-photocoagulation. Confocal microscopic analysis demonstrated an increase in CNV complex size in rats fed with alcohol (2.3-fold), nicotine (1.9-fold), and the combination of alcohol and nicotine (2.7-fold) compared with the control groups. Immunohistochemical analysis revealed that alcohol and nicotine consumption increased MAC deposition and VEGF expression in laser spots. Expression of CD59 by RT-PCR and Western blot was drastically reduced in the animals that were fed with alcohol, nicotine and alcohol and nicotine compared to those fed with water alone and this was associated with exacerbation of CNV. |
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Authors:
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Sankaranarayanan Kaliappan; Purushottam Jha; Valeriy V Lyzogubov; Ruslana G Tytarenko; Nalini S Bora; Puran S Bora |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-09-24 |
Journal Detail:
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Title: FEBS letters Volume: 582 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-12-10 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3451-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Pat and Willard Walker Eye Research Center, Jones Eye Institute, 4301 West Markham, Mail Slot 523, Little Rock, AR 72205, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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metabolism,
pathology* Animals Choroidal Neovascularization / metabolism, pathology* Complement Membrane Attack Complex / metabolism Ethanol / toxicity* Male Nicotine / toxicity* Rats Rats, Inbred BN |
| Grant Support | |
ID/Acronym/Agency:
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1 S10 RR 19395/RR/NCRR NIH HHS; 2 P20 RR 16460/RR/NCRR NIH HHS; EY 014623/EY/NEI NIH HHS; EY 016205/EY/NEI NIH HHS; S10 RR019395-01A1/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Complement Membrane Attack Complex; 54-11-5/Nicotine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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