Document Detail


Alcohol-mediated tactile conditioned aversions in infant rats: devaluation of conditioning through alcohol-sucrose associations.
MedLine Citation:
PMID:  8946405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three experiments were conducted to assess the plasticity of ethanol-mediated conditioned aversions to a tactile stimulus in infant rats. Ten- and 11-day-old rats first acquired an aversion to a texture, by virtue of its pairing with alcohol-induced intoxication. This first conditioning phase was followed by an associative devaluation procedure, a second phase in which sucrose was intraorally infused during alcohol-induced intoxication. Pups were then tested for their texture preference. Results indicated that infant rats readily express conditioned aversion to a tactile cue as a result of tactile-alcohol pairings and that this associative learning was not state dependent. When alcohol-texture conditioning was followed by sucrose-alcohol pairings, the magnitude of the texture aversion was dramatically reduced (Experiments 1 and 2). In Experiment 3 citric acid rather than sucrose was paired with alcohol intoxication following texture-alcohol pairings. The results indicated that this procedure strengthened texture conditioned aversions in terms of increased resistance to extinction. Taken as a whole these studies indicate that infants rapidly acquire alcohol-mediated texture aversions and that this memory is malleable and can be reduced or potentiated through manipulation of the representation of alcohol's unconditioned properties.
Authors:
J C Molina; M D Bannoura; M G Chotro; D L McKinzie; H M Arnold; N E Spear
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobiology of learning and memory     Volume:  66     ISSN:  1074-7427     ISO Abbreviation:  Neurobiol Learn Mem     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2007-10-17    
Medline Journal Info:
Nlm Unique ID:  9508166     Medline TA:  Neurobiol Learn Mem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-32     Citation Subset:  IM    
Affiliation:
Department of Psychology, Binghamton University, New York 13902-6000, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Conditioning (Psychology) / drug effects*
Ethanol / pharmacology*
Perception / drug effects*
Rats
Rats, Sprague-Dawley
Sucrose / pharmacology*
Chemical
Reg. No./Substance:
57-50-1/Sucrose; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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