| Alcohol-mediated tactile conditioned aversions in infant rats: devaluation of conditioning through alcohol-sucrose associations. | |
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MedLine Citation:
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PMID: 8946405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three experiments were conducted to assess the plasticity of ethanol-mediated conditioned aversions to a tactile stimulus in infant rats. Ten- and 11-day-old rats first acquired an aversion to a texture, by virtue of its pairing with alcohol-induced intoxication. This first conditioning phase was followed by an associative devaluation procedure, a second phase in which sucrose was intraorally infused during alcohol-induced intoxication. Pups were then tested for their texture preference. Results indicated that infant rats readily express conditioned aversion to a tactile cue as a result of tactile-alcohol pairings and that this associative learning was not state dependent. When alcohol-texture conditioning was followed by sucrose-alcohol pairings, the magnitude of the texture aversion was dramatically reduced (Experiments 1 and 2). In Experiment 3 citric acid rather than sucrose was paired with alcohol intoxication following texture-alcohol pairings. The results indicated that this procedure strengthened texture conditioned aversions in terms of increased resistance to extinction. Taken as a whole these studies indicate that infants rapidly acquire alcohol-mediated texture aversions and that this memory is malleable and can be reduced or potentiated through manipulation of the representation of alcohol's unconditioned properties. |
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Authors:
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J C Molina; M D Bannoura; M G Chotro; D L McKinzie; H M Arnold; N E Spear |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurobiology of learning and memory Volume: 66 ISSN: 1074-7427 ISO Abbreviation: Neurobiol Learn Mem Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1997-03-14 Completed Date: 1997-03-14 Revised Date: 2007-10-17 |
Medline Journal Info:
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Nlm Unique ID: 9508166 Medline TA: Neurobiol Learn Mem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 121-32 Citation Subset: IM |
Affiliation:
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Department of Psychology, Binghamton University, New York 13902-6000, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Conditioning (Psychology) / drug effects* Ethanol / pharmacology* Perception / drug effects* Rats Rats, Sprague-Dawley Sucrose / pharmacology* |
| Chemical | |
Reg. No./Substance:
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57-50-1/Sucrose; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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