Document Detail

Alcohol and marrow granulocyte reserve response to etiocholanolone.
MedLine Citation:
PMID:  7370378     Owner:  NLM     Status:  MEDLINE    
Measurement of the size of marrow granulocyte reserve (MGR) was performed in ten alcoholic patients with clinically uncomplicated Laennec's cirrhosis and in ten healthy subjects by etiocholanolone injection before and during oral 95% ethyl alcohol administration (30 to 60 ml in orange juice every 6 hours for 48 hours). No significant differences in bone marrow response to etiocholanolone were found between normal subjects studied before and during alcohol administration. The group of cirrhotic patients failed to demonstrate a reduction of MGR when compared to control subjects and alcohol administration did not result in an abnormal response to etiocholanolone. It is suggested that the MGR is normal in most alcoholic patients with clinically uncomplicated Laennec's cirrhosis and is not influenced by acute alcohol ingestion. These results are in contrast to other previous reports in which bacterial endotoxin was used to estimate granulocyte reserve.
G Chelazzi; E Verna; G M Mandelli Contegni; D Rossi; G Sala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedicine / [publiée pour l'A.A.I.C.I.G.]     Volume:  32     ISSN:  0300-0893     ISO Abbreviation:  Biomedicine     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361342     Medline TA:  Biomedicine     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  21-5     Citation Subset:  IM    
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MeSH Terms
Alcoholism / blood*
Bone Marrow / drug effects*
Bone Marrow Cells
Cell Movement / drug effects
Drug Interactions
Ethanol / pharmacology
Etiocholanolone / pharmacology*
Granulocytes / drug effects*,  physiology
Leukocyte Count
Liver Cirrhosis, Alcoholic / blood
Middle Aged
Reg. No./Substance:
53-42-9/Etiocholanolone; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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