| Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats. | |
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MedLine Citation:
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PMID: 20705416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic alcohol consumption causes severe hepatic oxidative damage, particularly to old subjects by decreasing various antioxidant enzymes. In this study, we test the hypothesis that exercise training can protect the aging liver against alcohol-induced oxidative damage. Two different age groups of Wistar albino rats (3 months young, n=24; 18 months old, n=24) were evenly divided into four groups: control (Con), exercise trained (Tr, 23 m/min 30 min/day, 5 days/week for 2 months), ethanol drinking/treated (Et, 2.0 g/kg b.w. orally), and exercise training plus ethanol drinking/treated (Tr+Et). We found significantly (P<.001) lowered hepatic antioxidant enzymes including superoxide dismutase, catalase, selenium (Se)-dependent glutathione peroxidase (Se-GSH-Px), Se-non-dependent glutathione peroxidase (non-Se-GSH-Px), glutathione reductase, and glutathione S-transferase activities in aged rats compared with young. Age-related decrease in antioxidant enzyme status was further exacerbated with ethanol drinking, which indicates liver in aged rats is more susceptible to oxidative damage because of decreased free radical scavenging system in aged/old ethanol-drinking rats. However, the decrease in liver antioxidant enzymes status with ethanol consumption was ameliorated by 2 months exercise training in old and young rats. These results demonstrate that age-associated decrease in hepatic free radical scavenging system exacerbated by ethanol drinking. For the first time, we found that this deterioration was significantly reversed by exercise training in aging liver, thus protects against alcohol-induced oxidative damage. |
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Authors:
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K Mallikarjuna; K R Shanmugam; K Nishanth; Ming-Chieh Wu; Chien-Wen Hou; Chia-Hua Kuo; K Sathyavelu Reddy |
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Publication Detail:
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Type: Journal Article Date: 2010-08-12 |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 44 ISSN: 1873-6823 ISO Abbreviation: Alcohol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
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Languages: eng Pagination: 523-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Zoology, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Antioxidants* Catalase / analysis Ethanol / administration & dosage, adverse effects* Glutathione Peroxidase / analysis Glutathione Reductase / analysis Glutathione Transferase / analysis Liver / enzymology* Liver Diseases, Alcoholic / prevention & control* Male Oxidative Stress Physical Conditioning, Animal* Rats Rats, Wistar Superoxide Dismutase / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 64-17-5/Ethanol; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 1.8.1.7/Glutathione Reductase; EC 2.5.1.18/Glutathione Transferase |
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