| Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF. | |
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MedLine Citation:
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PMID: 21930150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strong positive correlation between depression and alcoholism is evident in epidemiological reports. However, a causal relationship for this co-morbidity has not been established. We have observed that chronic daily exposure to a relatively high dose of alcohol can induce depressive-like behavior in rats and that pretreatment with nomifensine or imipramine can block the "depressogenic" effects of alcohol. Since brain derived neurotrophic factor (BDNF) is considered to play an important role in depressive-like behaviors and its elevation, particularly in the hippocampus, appears to be critical for the action of many antidepressants, we hypothesized that: 1. WKY rats, a putative animal model of depression, will show a lower hippocampal BDNF compared to their control Wistar rats, 2. Alcohol-induced depressive like behavior will be associated with a significant decrease in hippocampal BDNF and 3. Treatments with antidepressants will normalize hippocampal BDNF. These postulates were verified by measuring hippocampal BDNF in Wistar and WKY rats at baseline, following chronic (10 day) treatment with alcohol and combination of alcohol with nomifensine or imipramine. Alcohol was administered via inhalation chamber (3 h/day) such that a blood alcohol level of approximately 150 mg% was achieved. Nomifensine (10 mg/kg) or imipramine (10 mg/kg) was administered i.p. daily immediately after alcohol exposure. BDNF was measured by standard ELISA kit. The results support a role for central BDNF in depressogenic effects of alcohol and antidepressant effects of nomifensine and imipramine. Moreover, depression per se as manifested in WKY rats may be associated with a reduction in hippocampal BDNF. |
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Authors:
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Sheketha R Hauser; Bruk Getachew; Robert E Taylor; Yousef Tizabi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-09-10 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 100 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-10-21 Completed Date: 2012-02-16 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 253-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pharmacology, College of Medicine, Howard University, Washington, DC 20059, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain-Derived Neurotrophic Factor / metabolism* Depression / chemically induced* Ethanol / administration & dosage*, adverse effects Female Hippocampus / drug effects*, metabolism, physiology Rats Rats, Inbred WKY Rats, Wistar |
| Grant Support | |
ID/Acronym/Agency:
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2G12 RR003048/RR/NCRR NIH HHS; 2SO6 GM08016-39/GM/NIGMS NIH HHS; P20 AA014643/AA/NIAAA NIH HHS; P20 AA014643/AA/NIAAA NIH HHS; P20 AA014643-05/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 64-17-5/Ethanol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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