Document Detail

Alcohol exposure during the first two trimesters-equivalent alters the development of corpus callosum projection neurons in the rat.
MedLine Citation:
PMID:  18468834     Owner:  NLM     Status:  MEDLINE    
Children exposed prenatally to alcohol can display a variety of neural deficits, including an altered development of the corpus callosum (CC), the largest interhemispheric axon pathway in the brain. Furthermore, these children show functional abnormalities that are related to brain regions with significant numbers of CC connections. Little is known about how alcohol imparts influence on CC development, but one possible mechanism is by affecting the corpus callosum projection neurons (CCpn) directly. The purpose of this study was to quantify the effects of prenatal alcohol exposure on the number, size, and distribution of CCpn within the visual cortex. The visual cortex was selected specifically due to the many vision-related deficits noted in fetal alcohol exposed children and because the critical role of the CC in visual cortex development is well documented. Sprague-Dawley rat pups received one of four alcohol dosages during gestational days (G) 1-20, or reared as nutritional or untreated control animals. Each litter was categorized according to the peak blood alcohol concentration experienced. Pups were removed from each litter on days equivalent to G29, G36, G43, and G50, for histology and measurement. Callosal axons were labeled retrogradely to their CCpn using 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI) and the CCpn were then examined using confocal laser scanning microscopy. Differences between alcohol-exposed and control animals were observed in CCpn cell body size, number, and location with the cortex. This was particularly true of animals exposed to high doses of alcohol. In addition, some trends of CCpn development were found to be unchanged as a result of prenatal alcohol exposure. The results demonstrate clear differences in the development of CCpn in the visual cortex between alcohol-exposed and control animals and suggest that this development is particularly affected in those animals exposed to high doses of alcohol.
Daniel J Livy; Andrea J Elberger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-05-12
Journal Detail:
Title:  Alcohol (Fayetteville, N.Y.)     Volume:  42     ISSN:  0741-8329     ISO Abbreviation:  Alcohol     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-08-20     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8502311     Medline TA:  Alcohol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-93     Citation Subset:  IM    
Division of Anatomy, University of Alberta, Edmonton, Canada.
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MeSH Terms
Cell Count
Cell Size
Central Nervous System Depressants / toxicity*
Corpus Callosum / drug effects*,  embryology,  pathology
Dose-Response Relationship, Drug
Ethanol / toxicity*
Fetus / drug effects*
Fluorescent Dyes
Gestational Age
Maternal-Fetal Exchange*
Microscopy, Confocal
Neurons / drug effects*,  pathology
Rats, Sprague-Dawley
Visual Cortex / drug effects*,  embryology,  pathology
Grant Support
Reg. No./Substance:
0/Carbocyanines; 0/Central Nervous System Depressants; 0/Fluorescent Dyes; 40957-95-7/3,3'-dioctadecylindocarbocyanine; 64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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